Evidence map›Paper›PMID 31434710›Full record

ArticleMolecular & cellular proteomics : MCP2019

Multidimensional Proteomics Identifies Declines in Protein Homeostasis and Mitochondria as Early Signals for Normal Aging and Age-associated Disease in

Lu Yang, Ye Cao, Jing Zhao, Yanshan Fang, Nan Liu, Yaoyang Zhang

Abstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Mass spectrometry-based proteomics for biomarker discovery in theNeuroprotection (Chichester, England) · 2024
    Review
  3. Host response to Aplysia Abyssovirus 1 in nervous system and gill.Developmental and comparative immunology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. High-throughput proteomics: a methodological mini-review.Laboratory investigation; a journal of technical methods and pathology · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Slowed Protein Turnover in Aging Drosophila Reflects a Shift in Cellular Priorities.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  16. Article
  17. Article
  18. Regulation of Age-Related Protein Toxicity.Frontiers in cell and developmental biology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lu YangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, Shanghai, 201210, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Ye CaoInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, Shanghai, 201210, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Jing ZhaoInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, Shanghai, 201210, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Yanshan FangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, Shanghai, 201210, China.
Nan LiuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, Shanghai, 201210, China. Electronic address: liunan@sioc.ac.cn.
Yaoyang ZhangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, Shanghai, 201210, China. Electronic address: zyy@sioc.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is characterized by a gradual deterioration in proteome. However, how protein dynamics that changes with normal aging and in disease is less well understood. Here, we profiled the snapshots of aging proteome in

Indexed as

Down-RegulationAge of OnsetAgingAnimalsDisease Models, AnimalDrosophilaDrosophila ProteinsMaleMitochondriaMuscle, SkeletalMutationOrgan SpecificityParkinson DiseaseProtein Serine-Threonine KinasesProteomicsProteostasisDrosophila ProteinsPINK1 protein, DrosophilaProtein Serine-Threonine KinasesPTEN-Induced Putative KinaseagingDrosophila melanogastermitochondria function or biologyprotein synthesisproteome homeostasisquantification

Identifiers

PMID31434710
PMCPMC6773560

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.