Evidence map›Paper›PMID 31434678›Full record

ArticleGenome research2019

RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing.

Heidi Dvinge, Jamie Guenthoer, Peggy L Porter, Robert K Bradley

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 147 citations in OpenAlex.

  1. Article
  2. Experimental and therapeutic medicine · 2026
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  8. SUMO conjugation to promoter-proximal sequence elements-associated proteins impacts on snRNA transcription.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  12. Review
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Heidi DvingeComputational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Jamie GuenthoerHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Peggy L PorterHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Robert K BradleyComputational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Fred Hutch Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative splicing of pre-mRNAs plays a pivotal role during the establishment and maintenance of human cell types. Characterizing the

Indexed as

Alternative SplicingGene Expression Regulation, NeoplasticHumansNeoplasmsOrgan SpecificityRNARNA, MessengerRNA, Small NuclearRNA SplicingRNA Splicing FactorsSpliceosomesTranscriptomeRNARNA, MessengerRNA, Small NuclearRNA Splicing FactorsU4 small nuclear RNAU5 small nuclear RNAU6 small nuclear RNA

Identifiers

PMID31434678
PMCPMC6771400
OpenAlexW2969538625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.