Evidence map›Paper›PMID 31434643›Full record

ArticleBiology open2019

EGFP insertional mutagenesis reveals multiple FXR2P fibrillar states with differing ribosome association in neurons.

Emily E Stackpole, Michael R Akins, Maria Ivshina, Anastasia C Murthy, Nicolas L Fawzi, Justin R Fallon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Emily E StackpoleDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.
Michael R AkinsDepartment of Biology, Drexel University, Philadelphia, PA 19104, USA.
Maria IvshinaProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Anastasia C MurthyGraduate Program in Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.
Nicolas L FawziDepartment of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
Justin R FallonDepartment of Neuroscience, Brown University, Providence, RI 02912, USA Justin_Fallon@brown.edu.ORCID http://orcid.org/0000-0001-6673-4451
Brown University · USDrexel University · USUniversity of Massachusetts Chan Medical School · US

Funding

Neuroscience Advanced Predoctoral Institutional Training GrantT32NS062443 · NINDS · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE, MOORE, CHRISTOPHER I · 2008 to 2018
$1.8M
Turning off the molecular switch for pathological self-assembly of FUSR01GM118530 · NIGMS · BROWN UNIVERSITY · PI FAWZI, NICOLAS LUX · 2016 to 2020
$1.6M
Experience-dependent regulation of the Fragile X geneR01HD052083 · NICHD · BROWN UNIVERSITY · PI FALLON, JUSTIN R. · 2006 to 2010
$1.3M
Presynaptic Fragile X ProteinsR00MH090237 · NIMH · DREXEL UNIVERSITY · PI AKINS, MICHAEL R · 2013 to 2015
$747k
Presynaptic Fragile X ProteinsK99MH090237 · NIMH · BROWN UNIVERSITY · PI AKINS, MICHAEL R · 2010 to 2011
$180k
NICHD NIH HHS R01 HD052083NIGMS NIH HHS R01 GM118530NIMH NIH HHS K99 MH090237NIMH NIH HHS R00 MH090237NINDS NIH HHS T32 NS062443
6 · The paper itself

Abstract

RNA-binding proteins (RBPs) function in higher-order assemblages such as RNA granules to regulate RNA localization and translation. The Fragile X homolog FXR2P is an RBP essential for formation of neuronal Fragile X granules that associate with axonal mRNA and ribosomes in the intact brain. However, the FXR2P domains important for assemblage formation in a cellular system are unknown. Here we used an EGFP insertional mutagenesis approach to probe for FXR2P intrinsic features that influence its structural states. We tested 18 different in-frame FXR2P

Indexed as

Fragile X syndromeLocal protein synthesisLow complexityRNA-binding proteinRNA granule

Identifiers

PMID31434643
PMCPMC6737979
OpenAlexW2969928218

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.