ReviewNutrients2019
Lifestyle and Metabolic Syndrome: Contribution of the Endocannabinoidome.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06040164 (Molecular Study of Oral Dysbacteriosis in People With Prediabetes and Diabetes), which is not on this map. Cited by 81 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Study of Oral Dysbacteriosis in People With Prediabetes and Diabetes
Who cites it
81 citing papers in PubMed, 4 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Intake or Blood Levels of Magnesium and Risk of Metabolic Syndrome: A Meta-Analysis of Observational Studies.Nutrients · 2025Pooled it
- Associations of cadmium exposure with risk of metabolic syndrome and its individual components: a meta-analysis.Journal of exposure science & environmental epidemiology · 2023Pooled it
- Sleep Duration and the Risk of Metabolic Syndrome in Adults: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Effect of a Wearable Device-Based Physical Activity Intervention in North Korean Refugees: Pilot Randomized Controlled Trial.Journal of medical Internet research · 2023Trial
- Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study.Scientific reports · 2022Trial
- Beneficial Effects ofCells · 2021Trial
- Trial
- Endocannabinoids and related lipids in host metabolism-gut microbiome signalling.Nature reviews. Endocrinology · 2026Review
- Longitudinal changes in endocannabinoidome and dietary lipid profile in severe obesity: impact of sleeve gastrectomy.Lipids in health and disease · 2026Article
- Associations Between Metabolic Score for Visceral Fat and Venous Thromboembolism Among 118 619 Participants With Metabolic Syndrome: Insights From Epidemiology to Genetic Susceptibility.Journal of the American Heart Association · 2026Article
- Dietary fiber fermentation restores microbiome resilience to oxygen stress in a host-independentmBio · 2026Article
- Metabolic syndrome and a broken heart: trust your gut or risk your heart.American journal of physiology. Heart and circulatory physiology · 2026Review
- Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions.Liver international : official journal of the International Association for the Study of the Liver · 2026Review
- Maternal docosahexaenoic acid and eicosapentaenoic acid supplementation: effects and mechanisms on lipid metabolism in the offspring.Frontiers in nutrition · 2026Review
- Chemical Probes for Investigating the Endocannabinoid System.Current topics in behavioral neurosciences · 2026Review
- Emerging roles of cannabinoid pathways in renal injury and repair.Frontiers in pharmacology · 2026Review
- Seasonal variations in circulating endocannabinoidome mediators and gut microbiota composition in humans.Gut microbes · 2025Article
- The effects of cannabidiol on nitric oxide synthases: a narrative review on therapeutic implications for inflammation and oxidative stress in health and disease.Journal of cannabis research · 2025Review
- Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Lifestyle is a well-known environmental factor that plays a major role in facilitating the development of metabolic syndrome or eventually exacerbating its consequences. Various lifestyle factors, especially changes in dietary habits, extreme temperatures, unusual light-dark cycles, substance abuse, and other stressful factors, are also established modifiers of the endocannabinoid system and its extended version, the endocannabinoidome. The endocannabinoidome is a complex lipid signaling system composed of a plethora (>100) of fatty acid-derived mediators and their receptors and anabolic and catabolic enzymes (>50 proteins) which are deeply involved in the control of energy metabolism and its pathological deviations. A strong link between the endocannabinoidome and another major player in metabolism and dysmetabolism, the gut microbiome, is also emerging. Here, we review several examples of how lifestyle modifications (westernized diets, lack or presence of certain nutritional factors, physical exercise, and the use of cannabis) can modulate the propensity to develop metabolic syndrome by modifying the crosstalk between the endocannabinoidome and the gut microbiome and, hence, how lifestyle interventions can provide new therapies against cardiometabolic risk by ensuring correct functioning of both these systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.