Evidence map›Paper›PMID 31434288›Full record

ArticleGenes2019

The Role of

Luciana Tovo-Rodrigues, Gabriela Callo Quinte, Clarice Brinck Brum, Gabriele Ghisleni, Clarissa Ribeiro Bastos, Isabel Oliveira de Oliveira, Fernando C Barros, Aluisio J D Barros, Iná S Santos, Luis A Rohde and 2 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Luciana Tovo-RodriguesPostgraduate Program In Health and Behavior, Catholic University of Pelotas., Pelotas, Rio Grande do Sul 96015-560, Brazil. luciana.tovo@gmail.com.
Gabriela Callo QuintePostgraduate Program In Health and Behavior, Catholic University of Pelotas., Pelotas, Rio Grande do Sul 96015-560, Brazil.ORCID 0000-0003-4479-2014
Clarice Brinck BrumPostgraduate Program In Health and Behavior, Catholic University of Pelotas., Pelotas, Rio Grande do Sul 96015-560, Brazil.
Gabriele GhisleniLaboratory of Clinical Neuroscience, Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul 96015-560, Brazil.ORCID 0000-0002-1764-6882
Clarissa Ribeiro BastosLaboratory of Clinical Neuroscience, Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul 96015-560, Brazil.
Isabel Oliveira de OliveiraPostgraduate Program In Health and Behavior, Catholic University of Pelotas., Pelotas, Rio Grande do Sul 96015-560, Brazil.
Fernando C BarrosPostgraduate Program In Health and Behavior, Catholic University of Pelotas., Pelotas, Rio Grande do Sul 96015-560, Brazil.
Aluisio J D BarrosPostgraduate Program In Health and Behavior, Catholic University of Pelotas., Pelotas, Rio Grande do Sul 96015-560, Brazil.
Iná S SantosPostgraduate Program In Health and Behavior, Catholic University of Pelotas., Pelotas, Rio Grande do Sul 96015-560, Brazil.
Luis A RohdeDepartment of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90035-007, Brazil.
Mara H HutzProgram in Genetics and Molecular Biology Universidade Federal do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul 91501-970, Brazil.
Alicia MatijasevichDepartamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo 01246-903, Brasil.
Universidade Federal de Pelotas · BRUniversidade Católica de Pelotas · BRUniversidade Federal do Rio Grande do Sul · BRUniversidade de São Paulo · BR

Funding

Wellcome Trust 2009 to 2013
6 · The paper itself

Abstract

backgroundIt has been suggested that microRNAs (miRNAs; short non-protein-coding RNA molecules that mediate post-transcriptional regulation), including mir-9 and mir-34 families, are important for brain development. Current data suggest that mir-9 and mir-34 may have shared effects across psychiatric disorders. This study aims to explore the role of genetic polymorphisms in the

methodsPsychiatric disorders were assessed in 3585 individuals using Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), criteria through the application of standard semi-structured interviews (using the Development and Well-Being Assessment, DAWBA) at the six-years-of-age follow-up. The outcome was defined as the presence of any mental disorder. We also considered two broad groups of internalizing and externalizing disorders to further investigate the role of these variants in mental health.

resultsWe observed an association between rs4916723 (

conclusionThe study suggests that

Indexed as

Polymorphism, Single NucleotideChildChild, PreschoolFemaleHumansMaleMental DisordersMicroRNAsMicroRNAsMIRN34 microRNA, humanMIRN92 microRNA, humanbirth cohortgeneticsmental healthmicroRNA

Identifiers

PMID31434288
PMCPMC6723948
OpenAlexW2969846101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.