ArticleNutrients2019
Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations.
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Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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16citing papers in PubMed, 3 pooled it
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Plasma 25-hydroxyvitamin D deficiency in the peri-operative period is associated with survival outcome in colorectal cancer patients: a meta-analysis.BMC surgery · 2024Pooled it
- The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study.Nutrients · 2021Pooled it
- Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review.Nutrients · 2021Pooled it
- Vitamin D₃ in cancer prevention and therapy: molecular mechanisms, clinical evidence, and future perspectives.Molecular biology reports · 2026Review
- NCOA7 inhibits renal cancer progression by inducing autophagy and lipid metabolism through V-ATPase interaction.Cell death discovery · 2025Article
- Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations.Mutagenesis · 2025Article
- Cancer prevention: past challenges and future directions.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025Review
- Review
- Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer.BMC medicine · 2023Article
- Adequate vitamin D level associated with reduced risk of sporadic colorectal cancer.Frontiers in nutrition · 2023Article
- Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions.Journal of cancer prevention · 2022Review
- Genomic Alteration Characterization in Colorectal Cancer Identifies a Prognostic and Metastasis Biomarker: FAM83A|IDO1.Frontiers in oncology · 2021Article
- Identification of Vitamin D-related gene signature to predict colorectal cancer prognosis.PeerJ · 2021Article
- Association of prediagnostic vitamin D status with mortality among colorectal cancer patients differs by common, inherited vitamin D-binding protein isoforms.International journal of cancer · 2020Article
- Vitamin D-Induced Molecular Mechanisms to Potentiate Cancer Therapy and to Reverse Drug-Resistance in Cancer Cells.Nutrients · 2020Review
- Article
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Authors and funding
43 authors at 20 institutions in 13 countries.
Veronika FedirkoRollins School of Public Health, Emory University, Atlanta, GA 30322, USA. vfedirk@emory.edu.ORCID 0000-0002-7805-9913
Hannah B MandleRollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-0277-9607
Wanzhe ZhuRollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
David J HughesCancer Biology and Therapeutics Group (CBT), Conway Institute, School of Biomolecular and Biomedical Science (SBBS), University College Dublin, Dublin, Ireland.ORCID 0000-0003-1668-8770
Afshan SiddiqGenomics England, London EC1M 6BQ, UK.
Pietro FerrariSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon 69372, France.
Isabelle RomieuSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon 69372, France.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Bas Bueno-de-MesquitaDivision of Human Nutrition & Health, Wageningen University & Research, 6700 AA Wageningen, The Netherlands.
Fränzel J B van DuijnhovenDivision of Human Nutrition & Health, Wageningen University & Research, 6700 AA Wageningen, The Netherlands.
Peter D SiersemaDepartment of Gastroenterology and Hepatology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Anne TjønnelandDanish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Anja OlsenDanish Cancer Society Research Center, 2100 Copenhagen, Denmark.ORCID 0000-0003-4788-503X
Vittorio PerducaLaboratoire de Mathématiques Appliquées MAP5, Université Paris Descartes, 75006 Paris, France.ORCID 0000-0003-0339-0473
Franck CarbonnelCESP, Fac. de médecine-Univ. Paris-Sud, Fac. de médecine-UVSQ, INSERM, Université Paris-Saclay, F-94805 Villejuif, France.
Marie-Christine Boutron-RuaultCESP, Fac. de médecine-Univ. Paris-Sud, Fac. de médecine-UVSQ, INSERM, Université Paris-Saclay, F-94805 Villejuif, France.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Theron JohnsonDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Aleksandrova KrasimiraNutrition, Immunity and Metabolism, Department of Epidemiology, German Institute for Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert Allee, 14558 Nuthetal, Germany.
Antonia TrichopoulouHellenic Health Foundation, 115 27 Athens, Greece.
Periklis MakrythanasisHellenic Health Foundation, 115 27 Athens, Greece.
Dimitris ThanosHellenic Health Foundation, 115 27 Athens, Greece.
Salvatore PanicoDipartimento Di Medicina Clinica E Chirurgia, Federico Ii University, 80138 Naples, Italy.
Vittorio KroghEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 20133 Milano, Italy.ORCID 0000-0003-0122-8624
Carlotta SacerdoteUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), 10126 Turin, Italy.ORCID 0000-0002-8008-5096
Guri SkeieDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway.
Elisabete WeiderpassDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway.
Sandra Colorado-YoharDepartment of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia 30008, Spain.
Núria SalaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, and Translational Research Laboratory, Catalan Institute of Oncology (ICO)-IDIBELL, 08908 Barcelona, Spain.
Aurelio BarricarteCIBER Epidemiology and Public Healh (CIBERESP), Madrid 28029, Spain.
Maria-Jose SanchezCIBER Epidemiology and Public Healh (CIBERESP), Madrid 28029, Spain.
Ramón QuirósPublic Health Directorate, Asturias 33006, Spain.
Pilar AmianoCIBER Epidemiology and Public Healh (CIBERESP), Madrid 28029, Spain.
Björn GyllingDepartment of Medical Biosciences, Pathology, Umeå University, 901 87 Umeå, Sweden.
Sophia HarlidDepartment of Radiation Sciences, Oncology, Umeå University, 901 87 Umeå, Sweden.
Aurora Perez-CornagoCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Alicia K HeathDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Konstantinos K TsilidisDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Dagfinn AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Heinz FreislingSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon 69372, France.ORCID 0000-0001-8648-4998
Neil MurphySection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon 69372, France.
Marc J GunterSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon 69372, France.
Mazda JenabSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon 69372, France. jenabm@iarc.fr.
Centre international de recherche sur le cancer · FREmory University · USUniversité Paris-Sud · FRBiomedical Research Foundation of the Academy of Athens · GRDanish Cancer Society · DKGerman Cancer Research Center · DEImperial College London · GBUmeå University · SEWageningen University & Research · NLBiogipuzkoa Health Research Institute · ESFederico II University Hospital · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITGenomics England · GBGerman Institute of Human Nutrition · DEGobierno del Principado de Asturias · ESHellenic Health Foundation · GRInstitut Català d'Oncologia · ESInstituto de Investigación Biosanitaria de Granada · ESInstituto de Salud Pública de Navarra · ESKarolinska Institutet · SE
Funding
Cancer Research UK 14136Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1World Health Organization 001
Abstract
Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, and by gene/pathway) in 86 vitamin D-related genes in 1420 incident CRC cases matched to controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We also evaluated the association between these SNPs and circulating 25(OH)D in a subset of controls. We confirmed previously reported CRC risk associations between SNPs in the
Indexed as
AgedCase-Control StudiesColorectal NeoplasmsEuropeFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedNutritional Physiological PhenomenaPolymorphism, Single NucleotideProspective StudiesRisk FactorsSignal TransductionTransforming Growth Factor betaVitamin D25-hydroxyvitamin DTransforming Growth Factor betaVitamin Dcolorectal neoplasmsincidencesingle nucleotide polymorphism (SNP)vitamin D
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