ArticleMaterials (Basel, Switzerland)2019
A Novel Bilayer Polycaprolactone Membrane for Guided Bone Regeneration: Combining Electrospinning and Emulsion Templating.
Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 96 citations in OpenAlex.
- Development-based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Emulsion templating of PCL:PGS methacrylate blends for soft tissue engineering.Frontiers in bioengineering and biotechnology · 2026Article
- An Update Regarding the Use of Contemporary Dental Materials in Periodontal Regeneration.Materials (Basel, Switzerland) · 2025Review
- Implantable Dental Barrier Membranes as Regenerative Medicine in Dentistry: A Comprehensive Review.Tissue engineering and regenerative medicine · 2025Review
- Histological Evaluation of Subcutaneous Tissue Reactions to a Novel Bilayer Polycaprolactone/Silk Fibroin/Strontium Carbonate Nanofibrous Membrane for Guided Bone Regeneration: A Study in Rabbits.Clinical and experimental dental research · 2025Article
- The Chick Embryo Chorioallantoic Membrane (CAM) Assay: A Novel Experimental Model in Dental Research.Cureus · 2024Review
- Biomaterial Scaffolds for Periodontal Tissue Engineering.Journal of functional biomaterials · 2024Review
- Optimizing PCL/PLGA Scaffold Biocompatibility Using Gelatin from Bovine, Porcine, and Fish Origin.Gels (Basel, Switzerland) · 2023Article
- Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration.Marine drugs · 2023Article
- Guided Tissue and Bone Regeneration Membranes: A Review of Biomaterials and Techniques for Periodontal Treatments.Polymers · 2023Review
- Article
- Development of PCL PolyHIPE Substrates for 3D Breast Cancer Cell Culture.Bioengineering (Basel, Switzerland) · 2023Article
- Recent Advances on Electrospun Nanofibers for Periodontal Regeneration.Nanomaterials (Basel, Switzerland) · 2023Review
- Surfactant-free gelatin-stabilised biodegradable polymerised high internal phase emulsions with macroporous structures.Frontiers in chemistry · 2023Article
- Gelatin-containing porous polycaprolactone PolyHIPEs as substrates for 3D breast cancer cell culture and vascular infiltration.Frontiers in bioengineering and biotechnology · 2023Article
- Preparation of Interconnected Pickering Polymerized High Internal Phase Emulsions by Arrested Coalescence.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Advances in Electrospun Hybrid Nanofibers for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2022Review
- Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review.Polymers · 2022Review
- A "sweet" way to increase the metabolic activity and migratory response of cells associated with wound healing: deoxy-sugar incorporated polymer fibres as a bioactive wound patch.Turkish journal of biology = Turk biyoloji dergisi · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Guided bone regeneration is a common dental implant treatment where a barrier membrane (BM) is used between epithelial tissue and bone or bone graft to prevent the invasion of the fast-proliferating epithelial cells into the defect site to be able to preserve a space for infiltration of slower-growing bone cells into the periodontal defect site. In this study, a bilayer polycaprolactone (PCL) BM was developed by combining electrospinning and emulsion templating techniques. First, a 250 µm thick polymerised high internal phase emulsion (polyHIPE) made of photocurable PCL was manufactured and treated with air plasma, which was shown to enhance the cellular infiltration. Then, four solvent compositions were investigated to find the best composition for electrospinning a nanofibrous PCL barrier layer on PCL polyHIPE. The biocompatibility and the barrier properties of the electrospun layer were demonstrated over four weeks in vitro by histological staining. Following in vitro assessment of cell viability and cell migration, cell infiltration and the potential of PCL polyHIPE for supporting blood vessel ingrowth were further investigated using an ex-ovo chick chorioallantoic membrane assay. Our results demonstrated that the nanofibrous PCL electrospun layer was capable of limiting cell infiltration for at least four weeks, while PCL polyHIPE supported cell infiltration, calcium and mineral deposition of bone cells, and blood vessel ingrowth through pores.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.