ArticleViruses2019
Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation.
Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Analytical and Clinical Evaluation of the STANDARD M10 Arbovirus Panel for Dengue Detection, Serotyping, and Multiplex Arboviral Screening in the Americas.Diagnostics (Basel, Switzerland) · 2026Article
- Dengue epidemiology and transmission intensity across Panama during 2000-2024: a modelling study.Lancet regional health. Americas · 2026Article
- An Improved Dengue Virus Serotype-Specific Non-Structural Protein 1 Capture Immunochromatography Method with Reduced Sample Volume.Biosensors · 2025Article
- Seroprevalence of Arboviruses and Genetic Characterization of Orbiviruses in Sloths from Western Panama.Viruses · 2025Article
- Dynamics and genetic variation of dengue virus serotypes circulating during the 2022 outbreak in Karachi.Scientific reports · 2025Article
- Phylogenetics, Epidemiology and Temporal Patterns of Dengue Virus in Araraquara, São Paulo State.Viruses · 2024Article
- Epidemiological, virological and clinical characterization of a Dengue/Zika outbreak in the Caribbean region of Costa Rica 2017-2018.Frontiers in cellular and infection microbiology · 2024Article
- Detection of dengue virus serotype 4 in Panama after 23 years without circulation.Frontiers in cellular and infection microbiology · 2024Article
- Characteristics of Madariaga and Venezuelan Equine Encephalitis Virus Infections, Panama.Emerging infectious diseases · 2024Review
- Review
- Using compartmental models and Particle Swarm Optimization to assess Dengue basic reproduction numberHeliyon · 2023Article
- Molecular Characterization and Phylogenetic Analysis of Dengue Fever Viruses in Three Outbreaks in Tanzania Between 2017 and 2019.PLoS neglected tropical diseases · 2023Article
- Epidemiological and genomic analysis of dengue cases in Guangzhou, China, from 2010 to 2019.Scientific reports · 2023Article
- Insight into the seroepidemiology and dynamics of circulating serotypes of dengue virus over a 4 year period in western Uttar Pradesh, India.Access microbiology · 2023Article
- Spatio-temporal dynamics of dengue-related deaths and associated factors.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Review
- Assessing the Effect of Climate Variables on the Incidence of Dengue Cases in the Metropolitan Region of Panama City.International journal of environmental research and public health · 2021Article
- Dengue virus in humans and mosquitoes and their molecular characteristics in northeastern Thailand 2016-2018.PloS one · 2021Article
- Case Report: First Confirmed Case of Coinfection of SARS-CoV-2 WithFrontiers in tropical diseases · 2021Article
- Mass Cytometry Analysis of the NK Cell Receptor-Ligand Repertoire Reveals Unique Differences between Dengue-Infected Children and Adults.ImmunoHorizons · 2020Article
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Authors and funding
14 authors.
Funding
Abstract
Dengue virus (DENV) is the most prevalent arbovirus in terms of human public health importance globally. In addition to DENV epidemiological surveillance, genomic surveillance may help investigators understand the epidemiological dynamics, geographic distribution, and temporal patterns of DENV circulation. Herein, we aimed to reconstruct the molecular epidemiology and phylogeny of DENV in Panama to connect the epidemiological history of DENV dispersal and circulation in Latin America. We retrospectively analyzed the epidemiological data obtained during 25 years of DENV surveillance in Panama. DENV was reintroduced in Panama in 1993 after a 35 year absence of autochthonous transmission. The increase in the number of total dengue cases has been accompanied by an increase in severe and fatal cases, with the highest case fatality rate recorded in 2011. All four serotypes were detected in Panama, which is characterized by serotype replacement and/or co-circulation of multiple serotypes. Phylogenetic analysis of datasets collected from envelope (E) gene sequences obtained from viruses isolated from human sera demonstrated that circulating viruses were highly diverse and clustered in distinct clades, with co-circulation of clades from the same genotype. Our analyses also suggest that Panamanian strains were related to viruses from different regions of the Americas, suggesting a continuous exchange of viruses within the Americas.
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