Evidence map›Paper›PMID 31434191›Full record

ArticleInternational journal of molecular sciences2019

Perinatal Micro-Bleeds and Neuroinflammation in E19 Rat Fetuses Exposed to Utero-Placental Ischemia.

Ashtin B Giambrone, Omar C Logue, Qingmei Shao, Gene L Bidwell, Junie P Warrington

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  11. Edaravone Confers Neuroprotective, Anti-inflammatory, and Antioxidant Effects on the Fetal Brain of a Placental-ischemia Mouse Model.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ashtin B GiambroneDepartment of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Omar C LogueDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Qingmei ShaoDepartment of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Gene L BidwellDepartment of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Junie P WarringtonDepartment of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA. jpwarrington@umc.edu.ORCID 0000-0001-5626-8872
Jackson Memorial Hospital · USUniversity of Mississippi Medical Center · US

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca, Jane F Reckelhoff · 2017 to 2026
$26.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Center for Psychiatric NeuroscienceP30GM103328 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI STOCKMEIER, CRAIG ALLEN · 2013 to 2017
$5.5M
NIH HHS HL129192NIH HHS P20GM104357NIH HHS P30GM103328
6 · The paper itself

Abstract

Offspring of preeclampsia patients have an increased risk of developing neurological deficits and cognitive impairment. While low placental perfusion, common in preeclampsia and growth restriction, has been linked to neurological deficits, a causative link is not fully established. The goal of this study was to test the hypothesis that placental ischemia induces neuroinflammation and micro-hemorrhages

Indexed as

AnimalsBlood PressureChemokine CCL11Chemokine CXCL2Chemokine CXCL5FemaleFetusInflammationInterleukin-18Interleukin-1betaInterleukin-6IschemiaMaleMicrogliaPlacentaPregnancyChemokine CCL11Chemokine CXCL2Chemokine CXCL5Interleukin-18Interleukin-1betaInterleukin-6cerebral cytokinesmicro-bleedsmicrogliapreeclampsia

Identifiers

PMID31434191
PMCPMC6720786
OpenAlexW2969477485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.