SynthesisNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals.
Erratum issued Registry-linked trialOpen access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06809881 (OLFACTION AND BIPOLAR DISODER), which is not on this map. Cited by 114 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 10 pooled it
19.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Olfaction and bipolar disoder
Who cites it
114 citing papers in PubMed, 10 syntheses or guidelines pooled it, 227 citations in OpenAlex.
- White matter microstructure in relatives of people with schizophrenia or bipolar disorder: an ENIGMA meta-analysis.Molecular psychiatry · 2026Pooled it
- White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.Brain and behavior · 2026Pooled it
- Lithium effects in the frontolimbic circuitry: a systematic review of neuroimaging findings in bipolar disorder.Translational psychiatry · 2026Pooled it
- Associations between structural brain measures and cognitive function in bipolar disorder: a systematic review and meta-analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Pooled it
- Epigenome-wide association study of global cortical volumes in generation Scotland: Scottish family health study.Epigenetics · 2022Pooled it
- Glutamatergic and N-Acetylaspartate Metabolites in Bipolar Disorder: A Systematic Review and Meta-Analysis of Proton Magnetic Resonance Spectroscopy Studies.International journal of molecular sciences · 2022Pooled it
- A Comparative Multimodal Meta-analysis of Anisotropy and Volume Abnormalities in White Matter in People Suffering From Bipolar Disorder or Schizophrenia.Schizophrenia bulletin · 2022Pooled it
- The uncinate fasciculus in individuals with and at risk for bipolar disorder: A meta-analysis.Journal of affective disorders · 2022Pooled it
- White Matter Microstructure in Individuals With and At Risk for Bipolar Disorder: Evidence for an Endophenotype From a Voxel-Based Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.Biological psychiatry · 2026Article
- Brain imaging-derived phenotypes influence risk of bipolar disorder: comprehensive exposome-wide association and wide-angled genetic analyses.BMC medicine · 2026Article
- Biomarkers for mood disorders: A scoping review of research from India.Indian journal of psychiatry · 2026Review
- Article
- Immune dysregulation in mania: A proof-of-concept platelet proteomics study.Psychiatry and clinical neurosciences · 2026Article
- The role of neural derived extracellular vesicles micro-ribonucleic acid cargo in white matter integrity in early-onset and late-onset bipolar disorder.Molecular psychiatry · 2026Article
- Altered neurodevelopmental trajectories of brain structure in Tourette syndrome and Chronic Tic Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Delineating white matter phenotypes of sensori-/psychomotor functioning in large-scale cohorts of healthy individuals and patients with mental disorders across the lifespan (whiteSPAN): rationale and methods of an interdisciplinary bicentric project.European archives of psychiatry and clinical neuroscience · 2026Article
- Brain White Matter Microstructure in Middle and Older Aged Adults With Bipolar Disorder: A 2-Site Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.bioRxiv : the preprint server for biology · 2026Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
60 authors at 20 institutions in 13 countries.
Pauline FavreNeurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France. pauline@favre-univ.fr.ORCID http://orcid.org/0000-0002-8137-0358
Melissa PaulingNeurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Jacques StoutNeurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Franz HozerNeurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Samuel SarrazinNeurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Christoph AbéClinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Canada.ORCID http://orcid.org/0000-0001-9544-3944
Clara AllozaDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2092-8055
Silvia Alonso-LanaFIDMAG Research Foundation, Barcelona, Spain.
Ole A AndreassenDepartment of Mental Health and Addiction, University of Oslo, Oslo, Norway.
Bernhard T BauneDepartment of Psychiatry, University of Melbourne, Melbourne, Australia.
Francesco BenedettiDivision of Neuroscience, San Raffaele Scientific Institute, Milano, Italy.
Geraldo F BusattoLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Erick J Canales-RodríguezFIDMAG Research Foundation, Barcelona, Spain.
Xavier CaserasMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Tiffany Moukbel Chaim-AvanciniLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Christopher R K ChingInterdepartmental Neuroscience Program, University of California, Los Angeles, CA, USA.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
Michael DeppeUniversity of Münster, Department of Neurology, Münster, Germany.
Lisa T EylerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Mar Fatjo-VilasFIDMAG Research Foundation, Barcelona, Spain.
Sonya F FoleyCardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.
Dominik GrotegerdDepartment of Psychiatry, University of Münster, Münster, Germany.
Tomas HajekDepartment of Psychiatry, Dalhousie University, Halifax, Canada.
Unn K HaukvikDepartment of Mental Health and Addiction, University of Oslo, Oslo, Norway.
Fleur M HowellsDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Neda JahanshadInterdepartmental Neuroscience Program, University of California, Los Angeles, CA, USA.
Harald KugelUniversity of Muenster, Institute of Clinical Radiology, Münster, Germany.ORCID http://orcid.org/0000-0002-4349-1984
Trine V LagerbergDepartment of Mental Health and Addiction, University of Oslo, Oslo, Norway.
Stephen M LawrieDepartment of Psychiatry, Royal Edinburgh Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2444-5675
Julia O LinkeDepartment of Clinical Psychology and Neuropsychology, Johannes Gutenberg-Universität Mainz, Mainz, Germany.
Andrew McIntoshDepartment of Psychiatry, Royal Edinburgh Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
Elisa M T MelloniPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute and University Vita-Salute San Raffaele, Milano, Italy.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Sydney, Australia.
Mircea PolosanUniv. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France.
Edith Pomarol-ClotetFIDMAG Research Foundation, Barcelona, Spain.
Jonathan ReppleDepartment of Psychiatry, University of Münster, Münster, Germany.
Gloria RobertsSchool of Psychiatry, University of New South Wales, Sydney, Australia.
Annerine RoosDept of Psychiatry, SAMRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.
Pedro G P RosaLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Raymond SalvadorCIBERSAM, Barcelona, Spain.
Salvador SarróCIBERSAM, Barcelona, Spain.
Peter R SchofieldNeuroscience Research Australia, Sydney, Australia.ORCID http://orcid.org/0000-0003-2967-9662
Mauricio H SerpaDivision of Neuroscience, San Raffaele Scientific Institute, Milano, Italy.
Kang SimWest Region, Institute of Mental Health, Singapore, Singapore.
Dan J SteinDept of Psychiatry, SAMRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7218-7810
Jess E SussmannDepartment of Psychiatry, Royal Edinburgh Hospital, Edinburgh, UK.
Henk S TemminghDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, Los Angeles, CA, USA.
Norma VerdoliniFIDMAG Research Foundation, Barcelona, Spain.
Eduard VietaCIBERSAM, Barcelona, Spain.
Michele WessaDepartment of Clinical Psychology and Neuropsychology, Johannes Gutenberg-Universität Mainz, Mainz, Germany.
Heather C WhalleyDepartment of Clinical Psychology and Neuropsychology, Johannes Gutenberg-Universität Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0002-4505-8869
Marcus V ZanettiUniversity Vita-Salute San Raffaele, Milano, Italy.
Marion LeboyerNeurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Jean-François ManginNeurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Chantal HenryInstitut Pasteur, Unité Perception et Mémoire, Paris, France.
Edouard DuchesnayNeurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Josselin HouenouNeurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0003-3166-5606
ENIGMA Bipolar Disorder Working Group
Inserm · FRVita-Salute San Raffaele University · ITCentro de Investigación Biomédica en Red de Salud Mental · ESJohannes Gutenberg University Mainz · DEUniversity of Münster · DEDalhousie University · CAOslo University Hospital · NOSouth African Medical Research Council · ZACommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRUniversity of Southern California · USInstitut Pasteur · FRUniversity of California, Los Angeles · USUniversity of Cape Town · ZACenter for Neurosciences · USDélégation Paris 5 · FRFidmag Sisters Hospitallers · ESHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHospital General Universitario Gregorio Marañón · ESThe University of Melbourne · AUUniversité Paris-Est Créteil · FR
Funding
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5MTraining in the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer’s DiseaseT32AG058507 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2018 to 2026
$2.1MStructural and Functional Brain Aging in Bipolar DisorderR01MH083968 · NIMH · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI EYLER, LISA T · 2010 to 2014
$1.7MA global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA ConsortiumR01MH117601 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, SCHMAAL, LIANNE · 2018 to 2021
$1.5MMedical Research Council MR/L010305/1NIA NIH HHS T32 AG058507NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH083968NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601
Abstract
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R
Indexed as
AdultBipolar DisorderBrainCorpus CallosumDiffusion Tensor ImagingFemaleHumansMaleNeural PathwaysWhite Matter
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT06809881ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.