Evidence map›Paper›PMID 31434011›Full record

ArticlePsychiatry research2019

An introduction to effectiveness-implementation hybrid designs.

Sara J Landes, Sacha A McBain, Geoffrey M Curran

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 294 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
294citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07107906 narecruitingnot on this mapstarted 2025, after this paper: background citation

The CONNECT Program: Engaging Community Organizations in the Implementation and Evaluation of a Group Telehealth Mental Health Program for Older Canadians

TypeinterventionalSponsorUniversity of ManitobaRan2025 to 2026Enrolled128ConditionsLoneliness, Social Isolation, Depression Disorders, AnxietyArmsThe CONNECT Program, Community Participation as Usual (Service as Usual)
NCT07629219 nacompletednot on this mapstarted 2025, after this paper: background citation

Optimization of Low-Value Medical Testing Practices in Hospitalized Patients in Argentina (OPTIMIZAR)

TypeinterventionalSponsorHospital Italiano de Buenos AiresRan2025 to 2025Enrolled600ConditionsLow-Value Care, Costs and Cost Analysis, Implementation Science, Public HealthArmsOPTIMIZAR Multicomponent Diagnostic Stewardship Bundle
3 · Its place in the literature

Who cites it

294 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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234 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Sara J LandesThe Department of Veterans Affairs Quality Enhancement Research Initiative (QUERI) for Team-Based Behavioral Health, 2200 Fort Roots Drive, North Little Rock, AR 72114, USA; South Central Mental Illness Research Education and Clinical Center (MIRECC), Central Arkansas Veterans Healthcare System, 2200 Fort Roots Drive, North Little Rock, AR 72114, USA; University of Arkansas for Medical Sciences, Department of Psychiatry, 4301 W. Markham St, Little Rock, AR 72205, USA. Electronic address: sara.landes@va.gov.
Sacha A McBainSouth Central Mental Illness Research Education and Clinical Center (MIRECC), Central Arkansas Veterans Healthcare System, 2200 Fort Roots Drive, North Little Rock, AR 72114, USA; University of Arkansas for Medical Sciences, Department of Psychiatry, 4301 W. Markham St, Little Rock, AR 72205, USA.
Geoffrey M CurranSouth Central Mental Illness Research Education and Clinical Center (MIRECC), Central Arkansas Veterans Healthcare System, 2200 Fort Roots Drive, North Little Rock, AR 72114, USA; University of Arkansas for Medical Sciences, Department of Psychiatry, 4301 W. Markham St, Little Rock, AR 72205, USA; University of Arkansas for Medical Sciences, Department of Pharmacy Practice, 4301 W. Markham St, Little Rock, AR 72205, USA.

Funding

Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
NCATS NIH HHS UL1 TR003107
6 · The paper itself

Abstract

The traditional research pipeline that encourages a staged approach to moving an intervention from efficacy trials to the real world can take a long time. To address this issue, hybrid effectiveness-implementation designs were codified to promote examination of both effectiveness and implementation outcomes within a study. There are three types of hybrid designs and they vary based on their primary focus and the amount of emphasis on effectiveness versus implementation outcomes. A type 1 hybrid focuses primarily on the effectiveness outcomes of an intervention while exploring the "implementability" of the intervention. A type 2 hybrid has a dual focus on effectiveness and implementation outcomes; these designs allow for the simultaneous testing or piloting of implementation strategies during an effectiveness trial. A type 3 hybrid focuses primarily on implementation outcomes while also collecting effectiveness outcomes as they relate to uptake or fidelity of the intervention. This paper provides an introduction to these designs and describes each of the three types, design considerations, and examples for each.

Indexed as

Research DesignBiomedical ResearchClinical Trials as TopicHumansTreatment OutcomeHybrid effectiveness-implementation designImplementation

Identifiers

PMID31434011
PMCPMC6779135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.