ArticleJournal of the American Heart Association2019
Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- The ApoA5-Cidec axis: keeping fibrosis and MASLD at bay.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Endothelial-Specific Expression of CIDEC Improves High-Fat Diet-Induced Vascular and Metabolic Dysfunction.Diabetes · 2023Article
- Article
- A Novel Proangiogenic Function of Fsp27 in Endothelium: You Only Live Thrice?Journal of the American Heart Association · 2019Article
- Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity.Journal of the American Heart Association · 2019Article
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Authors and funding
12 authors at 2 institutions in 1 country.
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Abstract
Background Pathophysiological mechanisms that connect obesity to cardiovascular disease are incompletely understood. FSP27 (Fat-specific protein 27) is a lipid droplet-associated protein that regulates lipolysis and insulin sensitivity in adipocytes. We unexpectedly discovered extensive FSP27 expression in human endothelial cells that is downregulated in association with visceral obesity. We sought to examine the functional role of FSP27 in the control of vascular phenotype. Methods and Results We biopsied paired subcutaneous and visceral fat depots from 61 obese individuals (body mass index 44±8 kg/m
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