Evidence map›Paper›PMID 31433690›Full record

ArticleAmerican journal of physiology. Cell physiology2019

GABA receptors differentially regulate life span and health span in

Fengling Yuan, Jiejun Zhou, Lingxiu Xu, Wenxin Jia, Lei Chun, X Z Shawn Xu, Jianfeng Liu

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. UNC-49 is a redox-sensitive GABAScience advances · 2023
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Fengling YuanInternational Research Center for Sensory Biology and Technology of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Jiejun ZhouInternational Research Center for Sensory Biology and Technology of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Lingxiu XuInternational Research Center for Sensory Biology and Technology of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Wenxin JiaInternational Research Center for Sensory Biology and Technology of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Lei ChunInternational Research Center for Sensory Biology and Technology of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
X Z Shawn XuLife Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.
Jianfeng LiuInternational Research Center for Sensory Biology and Technology of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Huazhong University of Science and Technology · CNUniversity of Michigan–Ann Arbor · US

Funding

Neural and genetic mechanisms underlying behavior in C. elegans - Administrative Supplement for Equipment PurchasesR35GM126917 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2018 to 2025
$3.3M
NIGMS NIH HHS R35 GM126917
6 · The paper itself

Abstract

GABA, a prominent inhibitory neurotransmitter, is best known to regulate neuronal functions in the nervous system. However, much less is known about the role of GABA signaling in other physiological processes. Interestingly, recent work showed that GABA signaling can regulate life span via a metabotropic GABA

Indexed as

AgingAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCRISPR-Cas SystemsLongevityOxidative StressReceptors, GABASignal TransductionCaenorhabditis elegans ProteinsReceptors, GABAGABAhealth spanlife spanreceptors

Identifiers

PMID31433690
PMCPMC6879881
OpenAlexW2969890252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.