Evidence map›Paper›PMID 31433472›Full record

ArticleEuropean heart journal2019

Infective endocarditis after transcatheter aortic valve implantation: a nationwide study.

Henrik Bjursten, Magnus Rasmussen, Shahab Nozohoor, Mattias Götberg, Lars Olaison, Andreas Rück, Sigurdur Ragnarsson

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03768180 (INfecTive ENdocarditis After Transcatheter Aortic Valve Replacement), which is not on this map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03768180 completednot on this map

INfecTive ENdocarditis After Transcatheter Aortic Valve Replacement (TAVR) a National SwEdish Study (INTENSE)

TypeobservationalSponsorRegion SkaneRan2018 to 2019Enrolled4,600ConditionsInfective Endocarditis of Aortic Valve
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 123 citations in OpenAlex.

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  12. The Evolving Risk of Infective Endocarditis After Transcatheter Aortic Valve Implantation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Henrik BjurstenDepartment of Cardiothoracic Surgery, Lund University, Skåne University Hospital, Lund, Sweden.
Magnus RasmussenDepartment of Cardiothoracic Surgery, Lund University, Skåne University Hospital, Lund, Sweden.
Shahab NozohoorDepartment of Cardiothoracic Surgery, Lund University, Skåne University Hospital, Lund, Sweden.
Mattias GötbergDepartment of Cardiothoracic Surgery, Lund University, Skåne University Hospital, Lund, Sweden.
Lars OlaisonDepartment of Infectious Diseases, University of Gothenburg, Institute of Biomedicine, Gothenburg, Sweden.
Andreas RückDepartment of Aortic Valve Disease, Karolinska University Hospital, Stockholm, Sweden.
Sigurdur RagnarssonDepartment of Cardiothoracic Surgery, Lund University, Skåne University Hospital, Lund, Sweden.
Lund University · SEKarolinska University Hospital · SEUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTranscatheter aortic valve implantation (TAVI), now a common procedure to treat high-risk patients with severe aortic stenosis, has rapidly been expanding into younger and lower-risk populations, creating a need to better understand long-term outcome after TAVI. The aim of the present investigation was to determine the incidence, risk factors for, clinical presentation of, and outcome after prosthetic valve endocarditis (PVE) in patients treated with TAVI in a nationwide study. METHODS AND

resultsThree registries were used: a national TAVI registry, a national diagnosis registry, and a national infective endocarditis registry. Combining these registries made it possible to perform a nationwide, all-comers study with independent and validated reporting of PVE in 4336 patients between 2008 and mid-2018. The risk for PVE after TAVI was 1.4% (95% confidence interval 1.0-1.8%) the first year and 0.8% (0.6-1.1%) per year thereafter. One-year survival after PVE diagnosis was 58% (49-68%), and 5-year survival was 29% (17-41%). Body surface area, estimated glomerular filtration rate <30 mL/min/1.73 m2, critical pre-operative state, mean pre-procedural valve gradient, amount of contrast dye used, transapical access, and atrial fibrillation were identified as independent risk factors for PVE. Staphylococcus aureus was more common in early (<1 year) PVE. Infection with S. aureus, root abscess, late PVE, and non-community acquisition was associated with higher 6-month mortality.

conclusionThe incidence of PVE was similar to that of surgical bioprostheses. Compromised renal function was a strong risk factor for developing PVE. In the context of PVE, TAVI seems to be a safe option for patients. CLINICAL

trial registrationNCT03768180 (http://clinicaltrials.gov/).

Indexed as

Heart Valve ProsthesisAgedAged, 80 and overAortic Valve StenosisAtrial FibrillationBody Surface AreaContrast MediaEndocarditisFemaleFollow-Up StudiesGlomerular Filtration RateHumansIncidenceMalePatient AcuityProsthesis-Related InfectionsContrast MediaProsthetic valve endocarditisTranscatheter aortic valve implantation

Identifiers

PMID31433472
PMCPMC6911164
OpenAlexW2969831127

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.