ArticleJournal of experimental botany2019
FERONIA phosphorylates E3 ubiquitin ligase ATL6 to modulate the stability of 14-3-3 proteins in response to the carbon/nitrogen ratio.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- A phosphorylation-dependent ubiquitination switch orchestrates nuclear immune reprogramming upon chitin perception.Nature communications · 2026Article
- A molecular perspective on the role of FERONIA in root growth, nutrient uptake, stress sensing and microbiome assembly.Journal of advanced research · 2025Review
- Pangenome analysis reveals yield- and fiber-related diversity and interspecific gene flow in Gossypium barbadense L.Nature communications · 2025Article
- RALF-FER, a master ligand‒receptor pair in plant health.Crop health · 2025Review
- FERONIA: A Receptor Kinase at the Core of a Global Signaling Network.Annual review of plant biology · 2024Review
- Cellooligomer/CELLOOLIGOMER RECEPTOR KINASE1 Signaling Exhibits Crosstalk with PAMP-Triggered Immune Responses and Sugar Metabolism in Arabidopsis Roots.International journal of molecular sciences · 2024Article
- PYRIDOX(AM)INE 5'-PHOSPHATE OXIDASE3 of Arabidopsis thaliana maintains carbon/nitrogen balance in distinct environmental conditions.Plant physiology · 2023Article
- Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation.Plant communications · 2023Article
- Why is FERONIA pleiotropic?Nature plants · 2023Review
- TheInternational journal of molecular sciences · 2023Article
- Identification of Feronia-interacting proteins in Arabidopsis thaliana.Genes & genomics · 2022Article
- Reciprocal antagonistic regulation of E3 ligases controls ACC synthase stability and responses to stress.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Using chlorate as an analogue to nitrate to identify candidate genes for nitrogen use efficiency in barley.Molecular breeding : new strategies in plant improvement · 2021Article
- The enigma of environmental pH sensing in plants.Nature plants · 2021Review
- Roles of FERONIA-like receptor genes in regulating grain size and quality in rice.Science China. Life sciences · 2021Article
- The Ubiquitin Switch in Plant Stress Response.Plants (Basel, Switzerland) · 2021Review
- Phosphoproteomic Analysis of Thermomorphogenic Responses inFrontiers in plant science · 2021Article
- Versatile Roles of the Receptor-Like Kinase Feronia in Plant Growth, Development and Host-Pathogen Interaction.International journal of molecular sciences · 2020Review
- Improving coordination of plant growth and nitrogen metabolism for sustainable agriculture.aBIOTECH · 2020Review
- Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ratio between carbon (C) and nitrogen (N) utilization must be precisely coordinated to enable plant growth. Although numerous physiological studies have examined carbon/nitrogen (C/N) ratios, the mechanisms of sensing the C/N balance and C/N signaling remain elusive. Here, we report that a mutation of FERONIA (FER), a receptor kinase that plays versatile roles in plant cell growth and stress responses, caused hypersensitivity to a high C/N ratio in Arabidopsis. In contrast, FER-overexpressing plants displayed more resistant phenotypes. FER can interact with and phosphorylate ATL6, an E3 ubiquitin ligase that has been shown to regulate plant C/N responses. FER-mediated ATL6 phosphorylation enhanced the interaction between ATL6 and its previously identified target 14-3-3 proteins, thus decreasing 14-3-3 protein levels, leading to an increased insensitivity to high C/N ratios. Further analyses showed that the rapid alkalinization factor peptide (RALF1), which is a ligand of FER, also influenced the stability of 14-3-3 proteins via a FER-ATL6-mediated pathway. These findings reveal a novel regulatory mechanism that links the RALF1/FER-ATL6 pathway to whole-plant C/N responses and growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.