ReviewCurrent opinion in nephrology and hypertension2019
In-vivo techniques for determining nephron number.
Review in Current opinion in nephrology and hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Are noninvasive measurements of nephron number achievable in humans?Current opinion in nephrology and hypertension · 2026Review
- Association Analysis of theGenes · 2026Article
- Preserving nephron number in children after preterm birth: a top priority.Pediatric nephrology (Berlin, Germany) · 2026Article
- Morphometric analysis of retroperitoneal organs in individuals with unilateral congenital renal agenesis and renal hypoplasia.Pakistan journal of medical sciences · 2026Article
- Biopsy Morphometrics as Predictors of Treatment Response in Primary Nephrotic Syndrome.Kidney medicine · 2026Article
- Nephron number variability in Japanese subjects: an autopsy-based study and its implications for chronic kidney disease: clinical scientist award address 2024.Clinical and experimental nephrology · 2025Review
- Mice with aAmerican journal of physiology. Renal physiology · 2024Article
- Is Chronic Kidney Disease Due to Cadmium Exposure Inevitable and Can It Be Reversed?Biomedicines · 2024Review
- Renal MRI: From Nephron to NMR Signal.Journal of magnetic resonance imaging : JMRI · 2023Review
- Evidence Linking Cadmium Exposure and βToxics · 2023Article
- Chronic Kidney Disease Induced by Cadmium and Diabetes: A Quantitative Case-Control Study.International journal of molecular sciences · 2023Article
- The Validity of Benchmark Dose Limit Analysis for Estimating Permissible Accumulation of Cadmium.International journal of environmental research and public health · 2022Article
- The NOAEL Equivalent of Environmental Cadmium Exposure Associated with GFR Reduction and Chronic Kidney Disease.Toxics · 2022Article
- Nephron overload as a therapeutic target to maximize kidney lifespan.Nature reviews. Nephrology · 2022Review
- Quantitative renal magnetic resonance imaging: magnetic resonance urography.Pediatric radiology · 2022Review
- Image analysis techniques to map pyramids, pyramid structure, glomerular distribution, and pathology in the intact human kidney from 3-D MRI.American journal of physiology. Renal physiology · 2021Article
- Assessment of nephron number and single-nephron glomerular filtration rate in a clinical setting.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Review
- New imaging tools to measure nephron numberJournal of developmental origins of health and disease · 2021Review
- Magnetic resonance imaging accurately tracks kidney pathology and heterogeneity in the transition from acute kidney injury to chronic kidney disease.Kidney international · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purpose of reviewMany studies have suggested low nephron endowment at birth contributes to the risk of developing hypertension and chronic kidney disease (CKD) later in life. Loss of nephrons with age and disease is largely a subclinical process. New technologies are needed to count nephrons as glomerular filtration rate (GFR) is a poor surrogate for nephron number. RECENT
findingsCortical volume, glomerular density, and percent globally sclerotic glomeruli are imperfect surrogates for nephron number. The disector-fractionator method is the most accurate method to count nephrons but is limited to autopsy settings. Glomerular density combined with kidney imaging and ultrafiltration coefficient-based methods require a kidney biopsy, and have been applied in living humans (kidney donors). Low nephron number predicts a higher postdonation urine albumin. Contrast-enhanced MRI has detected glomeruli without a biopsy, but so far, not in living humans. SUMMARY: Currently, there is no accurate and well tolerated method for determining nephron number in living humans. A clinically useful method may allow GFR to be replaced by its more relevant determinants: nephron number and single nephron GFR. This could revolutionize nephrology by separating the measurement of chronic disease (nephron loss) from more reversible hemodynamic effects (nephron hyperfiltration/hypofiltration).
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