Evidence map›Paper›PMID 31433167›Full record

ArticleJournal of the American Chemical Society2019

Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling.

Franco Della-Felice, Ariel M Sarotti, Michael J Krische, Ronaldo A Pilli

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Franco Della-FeliceInstitute of Chemistry , University of Campinas (UNICAMP) , P.O. Box 6154, CEP 13083-970 Campinas , São Paulo , Brazil.ORCID 0000-0003-1131-9394
Ariel M SarottiInstituto de Química Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas , Universidad Nacional de Rosario-CONICET , Suipacha 531, S2002LRK Rosario , Argentina.ORCID 0000-0002-8151-0306
Michael J KrischeDepartment of Chemistry , University of Texas at Austin , Austin , Texas 78712 , United States.ORCID 0000-0001-8418-9709
Ronaldo A PilliInstitute of Chemistry , University of Campinas (UNICAMP) , P.O. Box 6154, CEP 13083-970 Campinas , São Paulo , Brazil.ORCID 0000-0002-5919-7763

Funding

Polyketides via Redox-Triggered Alcohol C-H Functionalization.R01GM093905 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI KRISCHE, MICHAEL J · 2011 to 2024
$4.5M
Bruker AVANCE III HD 500 MHz NMRS10OD021508 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L · 2016 to 2016
$529k
NIGMS NIH HHS R01 GM093905NIH HHS S10 OD021508
6 · The paper itself

Abstract

The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members.

Indexed as

AlcoholsAldehydesCatalysisIridiumMolecular StructureOxidation-ReductionPolyenesPyronesStereoisomerismAlcoholsAldehydesfostriecinIridiumPolyenesPyrones

Identifiers

PMID31433167
PMCPMC6737538

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.