Evidence map›Paper›PMID 31432715›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

Mitochondrial DNA variation modulates alveolar development in newborn mice exposed to hyperoxia.

Jegen Kandasamy, Gabriel Rezonzew, Tamas Jilling, Scott Ballinger, Namasivayam Ambalavanan

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

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  17. Swapping mitochondria: a key to understanding susceptibility to neonatal chronic lung disease.American journal of physiology. Lung cellular and molecular physiology · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jegen KandasamyDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
Gabriel RezonzewDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
Tamas JillingDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-6200-3851
Scott BallingerDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Namasivayam AmbalavananDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
University of Alabama at Birmingham · US

Funding

TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNGR01HL092906 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM · 2008 to 2012
$1.9M
NHLBI NIH HHS R01 HL092906
6 · The paper itself

Abstract

Hyperoxia-induced oxidant stress contributes to the pathogenesis of bronchopulmonary dysplasia (BPD) in preterm infants. Mitochondrial functional differences due to mitochondrial DNA (mtDNA) variations are important modifiers of oxidant stress responses. The objective of this study was to determine whether mtDNA variation independently modifies lung development and mechanical dysfunction in newborn mice exposed to hyperoxia. Newborn C57BL6 wild type (C57

Indexed as

Disease Models, AnimalGenetic VariationAnimalsAnimals, NewbornDNA, MitochondrialEnergy MetabolismFemaleHyperoxiaLungMiceMice, Inbred C3HMice, Inbred C57BLMitochondriaPulmonary AlveoliSuperoxidesDNA, MitochondrialSuperoxidesbioenergeticsbronchopulmonary dysplasiahyperoxiamitochondrialmitochondrial DNA

Identifiers

PMID31432715
PMCPMC6962596
OpenAlexW2969211428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.