Evidence map›Paper›PMID 31432707›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Antagonism of major histocompatibility complex class II invariant chain peptide during chronic lipopolysaccharide treatment rescues autoregulatory behavior.

Justin P Van Beusecum, Shali Zhang, Estevan Beltran, Anthony K Cook, Richard P Tobin, M Karen Newell-Rogers, Edward W Inscho

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Justin P Van BeusecumDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Shali ZhangDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Estevan BeltranSchool of Natural Sciences, University of California, Merced, Merced, California.
Anthony K CookDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Richard P TobinDivision of Surgical Oncology, Department of Surgery, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
M Karen Newell-RogersDepartment of Medical Physiology, Department of Medicine, Texas A&M Health Science Center, Temple, Texas.
Edward W InschoDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
University of Alabama at Birmingham · USTexas A&M Health Science Center · USUniversity of California, Merced · USUniversity of Colorado Denver · US

Funding

TLR4 in the Regulation of Renal Microvascular FunctionR01DK044628 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI INSCHO, EDWARD W · 2000 to 2021
$6.2M
The Inflammatory Cytokines, MCP-1 and TGF-Beta, Mediate Renal Autoregulatory ImpaR01HL098135 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI INSCHO, EDWARD W · 2010 to 2014
$1.8M
PURINERGIC REGULATION OF THE RENAL MICROVASCULATURER29DK044628 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI INSCHO, EDWARD W. · 1994 to 1998
–
NHLBI NIH HHS R01 HL098135NIDDK NIH HHS R01 DK044628NIDDK NIH HHS R29 DK044628
6 · The paper itself

Abstract

Toll-like receptor 4 (TLR4) activation contributes to vascular dysfunction in pathological conditions such as hypertension and diabetes, but the role of chronic TLR4 activation on renal autoregulatory behavior is unknown. We hypothesized that subclinical TLR4 stimulation with low-dose lipopolysaccharide (LPS) infusion increases TLR4 activation and blunts renal autoregulatory behavior. We assessed afferent arteriolar autoregulatory behavior in male Sprague-Dawley rats after prolonged LPS (0.1 mg·kg

Indexed as

AnimalsBlood PressureCyclic N-OxidesHistocompatibility Antigens Class IIHomeostasisLipopolysaccharidesMaleNephronsRatsRats, Sprague-DawleyReactive Oxygen SpeciesRenal CirculationSpin LabelsToll-Like Receptor 4VasoconstrictionCyclic N-OxidesHistocompatibility Antigens Class IILipopolysaccharidesReactive Oxygen SpeciesSpin LabelstempolTlr4 protein, ratToll-Like Receptor 4inflammationmajor histocompatibility complex class IIoxidative stressrenal microcirculationToll-like receptor 4

Identifiers

PMID31432707
PMCPMC6843034
OpenAlexW2969763027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.