Evidence map›Paper›PMID 31432633›Full record

ArticleAnnals of laboratory medicine2020

Performance of Copeptin for Early Diagnosis of Acute Myocardial Infarction in an Emergency Department Setting.

Ji Hun Jeong, Yiel Hea Seo, Jeong Yeal Ahn, Kyung Hee Kim, Ja Young Seo, Ka Yeong Chun, Yong Su Lim, Pil Whan Park

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of laboratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

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  5. Circular RNAs as Novel Biomarkers and Application in Cardiovascular Diseases.Advances in experimental medicine and biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ji Hun JeongDepartment of Laboratory Medicine, Chung Ang University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-5586-7889
Yiel Hea SeoDepartment of Laboratory Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0001-6849-122X
Jeong Yeal AhnDepartment of Laboratory Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0001-9842-0748
Kyung Hee KimDepartment of Laboratory Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0002-6433-454X
Ja Young SeoDepartment of Laboratory Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0002-1894-1365
Ka Yeong ChunDepartment of Internal Medicine, Gimpo Woori Hospital, Gimpo, Korea.ORCID https://orcid.org/0000-0002-1749-5850
Yong Su LimDepartment of Emergency Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0003-4390-4010
Pil Whan ParkDepartment of Laboratory Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea. pwpark@gilhospital.com.ORCID https://orcid.org/0000-0002-4955-6240
Gachon University · KRChung-Ang University Hospital · KRKimpo University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRapid and accurate diagnosis of acute myocardial infarction (AMI) is critical for initiating effective treatment and achieving better prognosis. We investigated the performance of copeptin for early diagnosis of AMI, in comparison with creatine kinase myocardial band (CK-MB) and troponin I (TnI).

methodsWe prospectively enrolled 271 patients presenting with chest pain (within six hours of onset), suggestive of acute coronary syndrome, at an emergency department (ED). Serum CK-MB, TnI, and copeptin levels were measured. The diagnostic performance of CK-MB, TnI, and copeptin, alone and in combination, for AMI was assessed by ROC curve analysis by comparing the area under the curve (AUC). Sensitivity, specificity, negative predictive value, and positive predictive value of each marker were obtained, and the characteristics of each marker were analyzed.

resultsThe patients were diagnosed as having ST elevation myocardial infarction (STEMI; N=43), non-ST elevation myocardial infarction (NSTEMI; N=25), unstable angina (N=78), or other diseases (N=125). AUC comparisons showed copeptin had significantly better diagnostic performance than TnI in patients with chest pain within two hours of onset (AMI:

conclusionsThe combination of TnI and copeptin improves AMI diagnostic performance in patients with early-onset chest pain in an ED setting.

Indexed as

Acute DiseaseAgedAngina, UnstableArea Under CurveCreatine Kinase, MB FormEarly DiagnosisEmergency Service, HospitalFemaleGlycopeptidesHumansMaleMiddle AgedMyocardial InfarctionNon-ST Elevated Myocardial InfarctionProspective StudiesROC CurvecopeptinsCreatine Kinase, MB FormGlycopeptidesTroponin IAcute myocardial infarctionCopeptinCreatine kinase myocardial bandNon-ST elevation myocardial infarctionPerformanceST elevation myocardial infarctionTroponin I

Identifiers

PMID31432633
PMCPMC6713663
OpenAlexW2969960966

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.