Evidence map›Paper›PMID 31432432›Full record

Trial reportAging clinical and experimental research2020

Effects of Tai Chi on beta endorphin and inflammatory markers in older adults with chronic pain: an exploratory study.

Tongjian You, Elisa F Ogawa, Saurja Thapa, Yurun Cai, Gloria Y Yeh, Peter M Wayne, Ling Shi, Suzanne G Leveille

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Chronic Pain in the Elderly: Mechanisms and Perspectives.Frontiers in human neuroscience · 2022
    Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Tongjian YouDepartment of Exercise and Health Sciences, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, 02125, USA. tongjian.you@umb.edu.ORCID http://orcid.org/0000-0002-3887-8201
Elisa F OgawaDepartment of Exercise and Health Sciences, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, 02125, USA.
Saurja ThapaDepartment of Nursing, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, 02125, USA.
Yurun CaiDepartment of Nursing, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, 02125, USA.
Gloria Y YehDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
Peter M WayneHarvard Medical School, Boston, MA, 02115, USA.
Ling ShiDepartment of Nursing, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, 02125, USA.
Suzanne G LeveilleDepartment of Nursing, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, 02125, USA.
University of Massachusetts Boston · USBrigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USMassachusetts College of Pharmacy and Health Sciences · USVA Boston Healthcare System · US

Funding

Mentoring and Patient-Oriented Research in Mind-Body ExerciseK24AT009465 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GLORIA Y YEH · 2017 to 2026
$1.3M
Mentoring and research in mind-body and integrative therapiesK24AT009282 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI WAYNE, PETER MICHAEL · 2017 to 2021
$834k
EFFECTS OF TAI CHI ON MULTISITE PAIN AND BRAIN FUNCTIONS IN OLDER ADULTSR21AG043883 · NIA · UNIVERSITY OF MASSACHUSETTS BOSTON · PI LEVEILLE, SUZANNE G., YOU, TONGJIAN · 2014 to 2015
$397k
NCCIH NIH HHS K24 AT009282NCCIH NIH HHS K24 AT009465NIA NIH HHS R21 AG043883NIH HHS R21 AG043883
6 · The paper itself

Abstract

The purpose of this exploratory study was to examine the effects of Tai Chi on blood levels of beta endorphin (β-endorphin) and inflammatory markers in older adults with chronic pain. Forty community-dwelling older adults with chronic pain were randomized to Tai Chi or light physical exercise, and each offered twice weekly for 12 weeks. Following the 12-week intervention, neither Tai Chi nor light physical exercise changed levels of β-endorphin and inflammatory markers. However, in older adults who completed 70% or more classes, Tai Chi significantly lowered levels of β-endorphin (p < 0.05), whereas light physical exercise did not change levels of β-endorphin. The results suggest that Tai Chi may reduce levels of β-endorphin in older adults with chronic pain. Future studies are needed to better understand the role of the opioid analgesic system and immune system in regulating pain with aging and the long-term effects of Tai Chi on pain-related biomarkers.

Indexed as

Tai JiAgedAged, 80 and overbeta-EndorphinBiomarkersChronic PainExerciseFemaleHumansIndependent LivingInflammationMalebeta-EndorphinBiomarkersBeta endorphinChronic painInflammationOlder adultsTai Chi

Identifiers

PMID31432432
PMCPMC7031034
OpenAlexW2969932994

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.