Evidence map›Paper›PMID 31432345›Full record

ArticleJournal of pharmacokinetics and pharmacodynamics2019

A quantitative systems pharmacology model of colonic motility with applications in drug development.

Raibatak Das, Lucia Wille, Liming Zhang, Chunlin Chen, Wendy Winchester, Jangir Selimkhanov, Jill Wykosky, Joshua F Apgar, John M Burke, Mark Rogge and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of pharmacokinetics and pharmacodynamics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Raibatak DasApplied BioMath, Concord, MA, USA.
Lucia WilleApplied BioMath, Concord, MA, USA.
Liming ZhangTakeda Pharmaceutical Inc., Cambridge, MA, USA.
Chunlin ChenTakeda Pharmaceutical Inc., Cambridge, MA, USA.
Wendy WinchesterTakeda Pharmaceutical Inc., Cambridge, MA, USA.
Jangir SelimkhanovTakeda Pharmaceutical Inc., Cambridge, MA, USA.
Jill WykoskyTakeda Pharmaceutical Inc., Cambridge, MA, USA.
Joshua F ApgarApplied BioMath, Concord, MA, USA.
John M BurkeApplied BioMath, Concord, MA, USA.
Mark RoggeTakeda Pharmaceutical Inc., Cambridge, MA, USA.
Fei HuaApplied BioMath, Concord, MA, USA.
Majid VakilynejadTakeda Pharmaceutical Inc., Cambridge, MA, USA. Majid.Vakilynejad@Takeda.com.ORCID http://orcid.org/0000-0002-2131-8769
Takeda (United States) · USApplied BioMath (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We developed a mathematical model of colon physiology driven by serotonin signaling in the enteric nervous system. No such models are currently available to assist drug discovery and development for GI motility disorders. Model parameterization was informed by published preclinical and clinical data. Our simulations provide clinically relevant readouts of bowel movement frequency and stool consistency. The model recapitulates healthy and slow transit constipation phenotypes, and the effect of a 5-HT

Indexed as

Models, BiologicalColonConstipationDrug DevelopmentGastrointestinal MotilityHumansMultiple SclerosisSerotonin Receptor AgonistsSerotonin Receptor Agonists5-HT4 receptorBowel dysfunctionColonConstipationEnteric nervous systemGI motilityQuantitative systems pharmacology

Identifiers

PMID31432345
OpenAlexW2969993477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.