Evidence map›Paper›PMID 31432328›Full record

ArticleTranslational stroke research2020

Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage.

Teck Chuan Lim, Emiri Mandeville, Ding Weng, Li-Shan Wang, Motoichi Kurisawa, Kimberly Leite-Morris, Magdy H Selim, Eng H Lo, Myron Spector

Abstract read
PubMed Publisher
In one paragraph

Article in Translational stroke research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
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  8. Nanobiotechnologies for stroke treatment.Nanomedicine (London, England) · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
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  15. Article
  16. Article
  17. Review
  18. Role of Ferroptosis in Stroke.Cellular and molecular neurobiology · 2023
    Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Teck Chuan LimHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. tclim@alum.mit.edu.
Emiri MandevilleNeuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital-East and Harvard Medical School, Room 2401, 149 13th Street, Charlestown, MA, 02129, USA.
Ding WengTissue Engineering Laboratories, Veterans Affairs Boston Healthcare System, Mail Stop 151, 150 S. Huntington Avenue, Boston, MA, 02130, USA.
Li-Shan WangInstitute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #07-01, Singapore, 138669, Singapore.
Motoichi KurisawaInstitute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #07-01, Singapore, 138669, Singapore.
Kimberly Leite-MorrisNeurochemistry and Behavioral Neuroscience Laboratory, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Magdy H SelimDepartment of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Eng H LoNeuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital-East and Harvard Medical School, Room 2401, 149 13th Street, Charlestown, MA, 02129, USA. lo@helix.mgh.harvard.edu.
Myron SpectorTissue Engineering Laboratories, Veterans Affairs Boston Healthcare System, Mail Stop 151, 150 S. Huntington Avenue, Boston, MA, 02130, USA. mspector@bwh.harvard.edu.
Harvard University · USInstitute of Bioengineering and Nanotechnology · SGVA Boston Healthcare System · USBrigham and Women's Hospital · USHarvard–MIT Division of Health Sciences and Technology · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We assessed an injectable gelatin hydrogel containing epidermal growth factor (Gtn-EGF) as a therapy for intracerebral hemorrhage (ICH). ICH was induced in rats via collagenase injection into the striatum. Two weeks later, Gtn-EGF was injected into the cavitary lesion. The hydrogel filled ICH cavities without deforming brain tissue. Immunostaining demonstrated that neural precursor cells could migrate into the matrix, and some of these differentiated into neurons along with the appearance of astrocytes, oligodendrocytes, and endothelial cells. Sensorimotor tests suggested that Gtn-EGF improved neurological recovery. This study provides proof-of-principle that injectable biomaterials may be a translationally relevant approach for treating ICH.

Indexed as

AnimalsBrainCerebral HemorrhageDisease Models, AnimalDrug Delivery SystemsEpidermal Growth FactorGelatinHydrogelsMaleNeuroprotective AgentsRats, Sprague-DawleyEpidermal Growth FactorGelatinHydrogelsNeuroprotective AgentsInjectable hydrogelNeural precursorsStroke cavity

Identifiers

PMID31432328
OpenAlexW2969374991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.