Evidence map›Paper›PMID 31432311›Full record

Trial reportClinical oral investigations2020

Anti-infective therapy of peri-implant mucositis with adjunctive delivery of a sodium hypochlorite gel: a 6-month randomized triple-blind controlled clinical trial.

Vincenzo Iorio-Siciliano, Andrea Blasi, Stefan-Ioan Stratul, Luca Ramaglia, Anton Sculean, Giovanni E Salvi, Darian Rusu

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. Local Oxygen-Based Therapy (blueMedicina (Kaunas, Lithuania) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vincenzo Iorio-SicilianoDepartment of Periodontology, University of Naples Federico II, Via S Pansini 5, Piata, 80131, Naples, Italy. enzois@libero.it.ORCID http://orcid.org/0000-0002-1968-0021
Andrea BlasiDepartment of Periodontology, University of Naples Federico II, Via S Pansini 5, Piata, 80131, Naples, Italy.
Stefan-Ioan StratulDepartment of Periodontology, Victor Babes University, Piata Eftimie 2, 300041, Timisoara, Romania.
Luca RamagliaDepartment of Periodontology, University of Naples Federico II, Via S Pansini 5, Piata, 80131, Naples, Italy.
Anton SculeanDepartment of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse, 7CH-3010, Bern, Switzerland.
Giovanni E SalviDepartment of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse, 7CH-3010, Bern, Switzerland.
Darian RusuDepartment of Periodontology, Victor Babes University, Piata Eftimie 2, 300041, Timisoara, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effects of adjunctive delivery of a sodium hypochlorite gel in the treatment of peri-implant mucositis (PM). MATERIALS AND

methodsForty-six subjects with 68 implants diagnosed with PM were randomly assigned to two treatment groups. Prior to mechanical debridement, a sodium hypochlorite gel was delivered to the implants of the test group while implants of the control group received a placebo gel. Application of both test and placebo gels was repeated 5 times at baseline. The primary outcome variable was the change in pocket probing depth (PPD) between baseline and 6 months.

resultsAfter 6 months, the mean PPD decreased statistically significantly from 3.93 ± 1.09 mm to 3.04 ± 0.46 mm in the test (p = 0.0001) and from 3.68 ± 0.85 mm to 3.07 ± 0.58 mm in the control (p = 0.0001) group, respectively. No statistically significant difference (p = 0.53) was observed with respect to PPD changes from baseline to 6 months between test (0.88 ± 1.04 mm) and control group (0.61 ± 0.75 mm), respectively. The number of implants with bleeding on probing (BoP) decreased statistically significantly from 33 to 18 in the test group (p = 0.0001) and from 34 to 23 in the control group (p = 0.0001) after 6 months.

conclusionsIn conclusion and within the limits of the present study, changes in PPD from baseline to 6 months were not statistically significantly different between groups. Complete resolution of mucosal inflammation was not achieved with either of the therapies. CLINICAL RELEVANCE: The present outcomes have showed that a complete resolution of peri-implant mucositis is not possible to obtain by means mechanical debridement with or without a sodium hypochlorite gel application.

Indexed as

Dental ImplantsMucositisPeri-ImplantitisSodium HypochloriteStomatitisGelsHumansPeriodontal IndexTreatment OutcomeDental ImplantsGelsSodium HypochloriteBiofilmBleeding on probingDental implantInflammationMucositisSodium hypochlorite

Identifiers

PMID31432311

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.