ArticleIntensive care medicine2019
Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design.
Article in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Extracorporeal carbon dioxide removal in acute hypoxaemic respiratory failure: a systematic review, Bayesian meta-analysis and trial sequential analysis.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- Extracorporeal COCritical care (London, England) · 2026Trial
- Impact of draining cannula position and configuration under high-flow extracorporeal COJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Article
- Lung- and diaphragm-protective mechanical ventilation in acute respiratory distress syndrome.Intensive care medicine · 2026Review
- ARDS management beyond the guidelines: a practical physiology-based approach to individualized care.Intensive care medicine · 2026Review
- Therapeutic Strategy of Extracorporeal Carbon Dioxide Removal in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Combined With Central Airway Stricture: A Case Report.Respirology case reports · 2026Article
- Practice and Perceptions on Extracorporeal Carbon Dioxide Removal in the Current Era: A Multinational Survey.The clinical respiratory journal · 2026Article
- A prospective clinical evaluation of new ECCO2R technology in mild to moderate ARDS patients: assessing ultra-lung-protective ventilation with PRISMALUNG.Critical care (London, England) · 2026Article
- Two Physiologic Latent Classes of Acute Hypoxemic Respiratory Failure in Sepsis Are Distinguished by Lung Mechanics and Gas Exchange.Critical care explorations · 2025Article
- "High blood flow" versus "low blood flow" ECCOCritical care (London, England) · 2025Article
- The role of extracorporeal COFrontiers in medicine · 2025Review
- Gattinoni's Legacy: Personalizing ARDS Management Through Physiology.Intensive care medicine · 2025Article
- Expert perspectives on ECCOAnnals of intensive care · 2024Article
- From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.American journal of respiratory and critical care medicine · 2024Review
- Driving pressure: applying the concept at the bedside.Intensive care medicine · 2023Article
- Dead space ventilation-related indices: bedside tools to evaluate the ventilation and perfusion relationship in patients with acute respiratory distress syndrome.Critical care (London, England) · 2023Review
- Extracorporeal carbon dioxide removal for acute respiratory failure: a review of potential indications, clinical practice and open research questions.Intensive care medicine · 2022Review
- Mechanical Ventilation during Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome: A Narrative Review.Journal of clinical medicine · 2021Review
- Alkaline Liquid Ventilation of the Membrane Lung for Extracorporeal Carbon Dioxide Removal (ECCOMembranes · 2021Article
- A preliminary cost-effectiveness analysis of lung protective ventilation with extra corporeal carbon dioxide removal (ECCOJournal of critical care · 2021Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 7 institutions in 4 countries.
Funding
Abstract
purposeTo describe the variability and determinants of the effect of extracorporeal CO
methodsUsing data from the SUPERNOVA trial (95 patients with early moderate acute respiratory distress syndrome), the independent effects of alveolar dead space fraction (ADF), respiratory system compliance (Crs), hypoxemia (PaO
resultsChanges in V
conclusionsThe lung-protective benefits of ECCO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.