ArticleInternational journal of molecular medicine2019
Differential expression of circRNAs during rat lung development.
Article in International journal of molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Dysregulated circRNA expression profile and associated miRNA sponging in abnormal lung development in congenital diaphragmatic hernia.Clinical and translational medicine · 2026Article
- Circular RNAs in the Origin of Developmental Lung Disease: Promising Diagnostic and Therapeutic Biomarkers.Biomolecules · 2023Review
- Microarray and Bioinformatics Analysis of Circular RNA Differential Expression in Newborns With Acute Respiratory Distress Syndrome.Frontiers in pediatrics · 2021Article
- Circular RNA expression profiles and features in NAFLD mice: a study using RNA-seq data.Journal of translational medicine · 2020Article
- [Continuous expression and functional prediction of circular RNA in mouse lung development].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Circular RNAs are abundant and dynamically expressed during the embryonic lung development of C57BL/6 mice.Heliyon · 2020Article
- Promotion of Bronchopulmonary Dysplasia Progression Using Circular RNA circabcc4 via Facilitating PLA2G6 Expression by Sequestering miR-663a.Frontiers in cell and developmental biology · 2020Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At present, thousands of circular RNAs (circRNAs) have been found in cancer and various tissues from different species. However, the expression of circRNAs during rat lung development remains largely unknown. In the present study, circRNA expression profiles were screened in three mixed rat lung tissues at 3 time‑points [embryonic day (E) 19, E21 and post‑natal (P) day 3] during fetal rat development with circRNA high‑throughput sequencing. Preliminary results were verified by reverse transcription‑PCR (RT‑PCR) at 4 time‑points (E16, E19, E21 and P3). A total of 375 circRNAs were differently expressed in E19 vs. E21 (fold change ≥1.5; P<0.05). At the same time, a total of 358 circRNAs were differently expressed in E21 vs. P3 (fold change ≥1.5; P<0.05). A total of 3 circRNAs (rno_circ:chr7:24777879‑24784993, rno_circ:chr14:14620910‑14624933 and rno_circ:chr3:1988750‑1998592) were characterized by having consistent fold changes (≥1.5) between 3 time‑points (E19, E21 and P3) and were selected for RT‑PCR at 4 time‑points (E16, E19, E21 and P3). Subsequently, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of parent genes of the differentially expressed circRNAs revealed that these circRNAs may serve important roles in lung development. The present results support that these new found circRNAs participate in lung development. Furthermore, these findings may help to clarify the physiopathological mechanism of normal rat lung development, and may further provide a physiopathological basis of lung developmental diseases.
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