ArticleMolecular medicine reports2019
MicroRNA‑217 is involved in the progression of atherosclerosis through regulating inflammatory responses by targeting sirtuin 1.
Article in Molecular medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- MicroRNAs as master regulators of macrophage function in atherosclerosis: From polarization to therapeutic potential.iScience · 2026Review
- Sirtuins in Medicine: Multifaceted Roles in Physiological Processes and Cardiovascular Diseases.Biomolecules · 2026Review
- The crosstalk between MicroRNAs and sirtuins: a bit unexpected therapeutic target for cardiovascular diseases.European journal of medical research · 2025Review
- In Silico Analysis of Possible microRNAs Involved in the Pathogenesis of White-Nose Syndrome inInternational journal of molecular sciences · 2025Article
- Epigenetic Mechanisms in Heart Diseases.Reviews in cardiovascular medicine · 2025Review
- Biochemical analysis of miR-217 and miR-532 in patients with fibromyalgia.European journal of medical research · 2025Article
- Research Progress on Histone Deacetylases Regulating Programmed Cell Death in Atherosclerosis.Journal of cardiovascular translational research · 2024Review
- MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses.Biogerontology · 2024Review
- MiR-217 Regulates SIRT1 Expression and Promotes Inflammatory and Apoptotic Responses in Osteoarthritis.Genes · 2023Article
- miR34a-5p impedes CLOCK expression in chronodisruptive C57BL/6J mice and potentiates pro-atherogenic manifestations.PloS one · 2023Article
- The sirtuin family in health and disease.Signal transduction and targeted therapy · 2022Review
- Midazolam Suppresses Hepatocellular Carcinoma Cell Metastasis and Enhances Apoptosis by Elevating miR-217.Computational and mathematical methods in medicine · 2022Article
- LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis.Cellular & molecular biology letters · 2021Article
- MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1.Oncology letters · 2021Article
- CircTM7SF3 contributes to oxidized low-density lipoprotein-induced apoptosis, inflammation and oxidative stress through targeting miR-206/ASPH axis in atherosclerosis cell model in vitro.BMC cardiovascular disorders · 2021Article
- NRF2-Related Epigenetic Modifications in Cardiac and Vascular Complications of Diabetes Mellitus.Frontiers in endocrinology · 2021Review
- Vascular Health Triad in Humans With Hypertension-Not the Usual Suspects.Frontiers in physiology · 2021Review
- Transcription Factor-7-Like-2 (TCF7L2) in Atherosclerosis: A Potential Biomarker and Therapeutic Target.Frontiers in cardiovascular medicine · 2021Review
- MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy.Cardiovascular diabetology · 2020Review
- MicroRNA-374 is a potential diagnostic biomarker for atherosclerosis and regulates the proliferation and migration of vascular smooth muscle cells.Cardiovascular diagnosis and therapy · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is a chronic inflammatory disease, and it is a global clinical problem. The development of new and effective therapeutic targets for atherosclerosis is necessary. A number of microRNAs (miRNAs) have been demonstrated to serve a crucial role in atherosclerosis. However, the role of miRNA (miR)‑217 in atherosclerosis remains unclear. Therefore, the aim of the present study was to investigate the role and mechanism of miR‑217 in atherosclerosis. The level of miR‑217 was detected in the blood of patients with atherosclerosis using reverse transcription‑quantitative PCR. THP‑1 acute monocytic leukemia cells were treated with oxidized low‑density lipoprotein (ox‑LDL) to develop an atherosclerotic cell model of macrophages. The relationship between miR‑217 and sirtuin 1 (SIRT1) was determined by TargetScan and dual luciferase reporter assay. Cell apoptosis was measured by flow cytometry. Production of pro‑inflammatory factors and triglyceride (TG) and total cholesterol (TC) levels were also determined. The results demonstrated that miR‑217 was significantly upregulated in atherosclerosis. SIRT1 was demonstrated to be a direct target of miR‑217 and was downregulated in atherosclerosis. Downregulation of miR‑217 significantly inhibited ox‑LDL‑induced TG and TC level increase, cell apoptosis and the upregulation of the pro‑inflammatory factors tumor necrosis factor α, interleukin (IL)‑6 and IL‑1β. Additionally, the SIRT1/AMP‑activated protein kinase α/NF‑κB pathway was at least partially involved in modulating the effects of miR‑217 inhibition on THP‑1 cells treated with ox‑LDL. In addition, the effects of miR‑217 downregulation on ox‑LDL‑treated THP‑1 cells were eliminated by SIRT1 silencing. In conclusion, the results of the present study indicated that miR‑217 downregulation may relieve atherosclerosis through the inhibition of macrophage apoptosis and inflammatory response by targeting SIRT1.
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