ArticleArchives of academic emergency medicine2019
Blood Urea Nitrogen to Creatinine ratio in Differentiation of Upper and Lower Gastrointestinal Bleedings; a Diagnostic Accuracy Study.
Article in Archives of academic emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Integrating the Urea-to-Creatinine Ratio with Clinical Variables to Improve Etiological Discrimination in Acute Kidney Injury.Journal of clinical medicine · 2026Article
- Dietary mimicry of melena following chocolate cookie ingestion in a patient with colostomy: a case report.Journal of medical case reports · 2026Article
- A primer on the imaging approach to acute gastrointestinal bleeding.Abdominal radiology (New York) · 2026Review
- An analysis of digoxin serum concentrations and influencing factors: A cross-sectional study from a tertiary hospital in China.Medicine · 2026Article
- Use of the blood urea nitrogen level to predict the rebleeding in patients with non-variceal upper gastrointestinal bleeding.Medicine · 2026Article
- Association between the blood urea nitrogen-albumin ratio and mortality in critically ill patients with gastrointestinal bleeding: a retrospective cohort study.BMC gastroenterology · 2025Article
- Diagnostic value of the urea-to-creatinine ratio for gastrointestinal bleeding source: influence of renal function.BMC nephrology · 2025Article
- The role of the Lactate-to-Albumin ratio in predicting ICU admission and mortality in patients with UGIB presenting to the ED: a prospective observational study.BMC emergency medicine · 2025Observational
- Lactate to albumin ratio as a prognosis predictor in gastrointestinal bleeding in the emergency department.Internal and emergency medicine · 2025Article
- The role of BUN/creatinine ratio in determining the severity of gastrointestinal bleeding and bleeding localization.Northern clinics of Istanbul · 2025Article
- Article
- Plasma urea:creatinine ratio as a biomarker of gastrointestinal bleeding in dogs with anaemia.Veterinary medicine and science · 2023Article
- Bleeding Complications in Uremic Patients After Ultrasound-Guided Central Venous Catheter Placement.Open access emergency medicine : OAEM · 2023Article
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFinding easily accessible and non-invasive methods for differentiating various sources of gastrointestinal (GI) bleeding before performing endoscopy and colonoscopy is of great interest. The present study was designed with the aim of evaluating the screening performance characteristics of blood urea nitrogen (BUN) to Creatinine (Cr) ratio in this regard.
methodsThe present diagnostic accuracy study was performed on patients with acute GI bleeding presenting to emergency department from 2011 to 2016, in a retrospective manner. BUN/Cr ratio was calculated for all patients and its accuracy in differentiation of upper and lower GI bleedings, confirmed via endoscopy or colonoscopy, was evaluated.
resultsA total of 621 patients with the mean age of 59.49±17.94 (5 - 93) years were studied (60.5% male). Area under the receiver operating characteristic (ROC) curve of BUN/Cr ratio for predicting the source of GI bleeding was 0.63 (95% CI: 0.57 - 0.68). Sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios of BUN/Cr ratio at 35 cut-off point were 19.63% (95%CI: 16.69 - 23.45), 90.16% (95%CI: 83.11 - 94.88), 89.09 (95%CI: 81.35 - 93.98), 21.53 (95%CI: 18.09 - 25.39), 8.16 (95%CI:4.76 - 13.98), and 3.65 (95%CI: 3.44 - 3.87), respectively.
conclusionConsidering the relatively proper specificity and positive predictive value of BUN/Cr ratio, in cases that bleeding source cannot be determined using other non-invasive methods, values higher than 35 can predict upper GI bleeding with high probability. However, due to the low sensitivity, values less than 35 are not diagnostic.
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31432040PMC6637801What OpenQuestion holds
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