ArticleRheumatology advances in practice2017
No structural cerebral MRI changes related to fatigue in patients with primary Sjögren's syndrome.
Article in Rheumatology advances in practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- A systematic review of digital and imaging technologies for measuring fatigue in immune mediated inflammatory diseases.NPJ digital medicine · 2025Article
- Neurological involvement in primary Sjögren's syndrome: a retrospective analysis of clinical, radiological, laboratory and therapeutic correlations.BMJ neurology open · 2025Article
- Central Nervous System Involvement in Primary Sjögren's Syndrome: Narrative Review of MRI Findings.Diagnostics (Basel, Switzerland) · 2022Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWhether or not chronic fatigue is reflected in structural changes in the brain is a matter of debate. Primary SS (pSS) is characterized by dryness of the mouth and eyes, migrating muscle and joint pain and prominent fatigue. We aimed to investigate whether the severity of fatigue in pSS was associated with cerebral MRI findings.
methodsFatigue was measured with the fatigue visual analog scale in 65 patients with pSS. Global grey matter (GM) and white matter volumes were estimated from magnetic resonance T1 images, and associations between fatigue and brain volumes were assessed in regression models. Voxel-based morphometric analyses of GM were performed to investigate possible associations between fatigue and GM volume changes in particular brain regions.
resultsThe fatigue scores in the patient group were spread across a wide range. Global volume analyses showed no significant effect of GM volumes and white matter volumes on fatigue. Voxel-wise analyses of GM did not identify any particular brain region associated with fatigue.
conclusionFatigue is a dominant phenomenon in pSS patients but is not reflected in structural abnormalities in the brain as visualized by conventional MRI. Our findings support the hypothesis of fatigue as a physiological phenomenon that does not lead to vascular changes or neuronal or glial death or damage.
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