Evidence map›Paper›PMID 31431918›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019

Biomagnetic biomarkers for dementia: A pilot multicentre study with a recommended methodological framework for magnetoencephalography.

Laura E Hughes, Richard N Henson, Ernesto Pereda, Ricardo Bruña, David López-Sanz, Andrew J Quinn, Mark W Woolrich, Anna C Nobre, James B Rowe, Fernando Maestú and 1 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Neurophysiological trajectories in Alzheimer's disease progression.bioRxiv : the preprint server for biology · 2024
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  15. Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura E HughesDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Richard N HensonMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Ernesto PeredaLaboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Madrid, Spain.
Ricardo BruñaLaboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Madrid, Spain.
David López-SanzLaboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Madrid, Spain.
Andrew J QuinnOxford Centre for Human Brain Activity, University of Oxford, Oxford, UK.
Mark W WoolrichOxford Centre for Human Brain Activity, University of Oxford, Oxford, UK.
Anna C NobreOxford Centre for Human Brain Activity, University of Oxford, Oxford, UK.
James B RoweDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Fernando MaestúLaboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Madrid, Spain.
BioFIND Working Group

Funding

Biotechnology and Biological Sciences Research Council BB/H008217/1Medical Research Council MC_UU_00005/12Medical Research Council MC_UU_00005/8Medical Research Council MR/L023784/2Wellcome Trust 103838
6 · The paper itself

Abstract

introductionAn increasing number of studies are using magnetoencephalography (MEG) to study dementia. Here we define a common methodological framework for MEG resting-state acquisition and analysis to facilitate the pooling of data from different sites.

methodsTwo groups of patients with mild cognitive impairment (MCI, n = 84) and healthy controls (n = 84) were combined from three sites, and site and group differences inspected in terms of power spectra and functional connectivity. Classification accuracy for MCI versus controls was compared across three different types of MEG analyses, and compared with classification based on structural MRI.

resultsThe spectral analyses confirmed frequency-specific differences in patients with MCI, both in power and connectivity patterns, with highest classification accuracy from connectivity. Critically, site acquisition differences did not dominate the results. DISCUSSION: This work provides detailed protocols and analyses that are sensitive to cognitive impairment, and that will enable standardized data sharing to facilitate large-scale collaborative projects.

Indexed as

Functional connectivityHarmonizationMagnetoencephalographyMild cognitive impairmentMulti-siteSpectral analysis

Identifiers

PMID31431918
PMCPMC6579903

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.