Evidence map›Paper›PMID 31431706›Full record

ReviewBone marrow transplantation2019

Combined kidney and hematopoeitic cell transplantation to induce mixed chimerism and tolerance.

Robert Lowsky, Samuel Strober

Abstract readReview
In one paragraph

Review in Bone marrow transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Combined nonmyeloablative total lymphoid irradiation and low-dose total body irradiation enhances donor chimerism and leads to islet allograft acceptance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Helical TomoTherapy Total Lymphoid Irradiation and Hematopoietic Cell Transplantation for Kidney Transplant Tolerance in Rhesus Macaques.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Moving from transplant as a treatment to transplant as a cure.The Journal of clinical investigation · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert LowskyDivisions of Blood and Marrow Transplantation and Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Samuel StroberDivisions of Blood and Marrow Transplantation and Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. sstrober@stanford.edu.

Funding

TLI/ATG CONDTIONING: KIDNEY/BLOOD STEM CELL TRANSPLANTSP01HL075462 · NHLBI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2004 to 2020
$27.9M
BMT Core - Stanford UniversityUG1HL069291 · NHLBI · STANFORD UNIVERSITY · PI Lori Muffly · 2017 to 2026
$1.7M
Gene and Cytokine Expression in Tolerance and GVHDR01AI085024 · NIAID · STANFORD UNIVERSITY · PI LOWSKY, ROBERT, SARWAL, MINNIE M · 2009 to 2012
$1.6M
NHLBI NIH HHS P01 HL075462NHLBI NIH HHS UG1 HL069291NIAID NIH HHS R01 AI085024
6 · The paper itself

Abstract

Based on preclinical studies, combined kidney and hematopoietic cell transplantation was performed on fully HLA matched and haplotype matched patients at the Stanford University Medical Center. The object of the studies was to induce mixed chimerism, immune tolerance, and complete immunosuppressive drug withdrawal. Tolerance, persistent mixed chimerism, and complete withdrawal was achieved in the majority of fully matched patients. Persistent mixed chimerism and partial withdrawal has been achieved in the haplotype matched patients at present.

Indexed as

ChimerismHematopoietic Stem Cell TransplantationHumansKidney TransplantationTransplantation Conditioning

Identifiers

PMID31431706
PMCPMC8185903

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.