Evidence map›Paper›PMID 31431652›Full record

ArticleScientific reports2019

ASIC3-dependent metabolomics profiling of serum and urine in a mouse model of fibromyalgia.

Wei-Hsiang Hsu, Cheng-Han Lee, Yen-Ming Chao, Ching-Hua Kuo, Wei-Chi Ku, Chih-Cheng Chen, Yun-Lian Lin

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05154695 nacompletednot on this mapstarted 2021, after this paper: background citation

Precision Medicine for Sng/Pain Control

TypeinterventionalSponsorNational Taiwan University HospitalRan2021 to 2023Enrolled80ConditionsRehabilitation, Pain, Shoulder, Pain, ChronicArmsLASER, A.therapeutic ultrasound group, B.prolotherapy group
NCT06161038 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Precision Medicine for Nociception, Sngception and Proprioception.

TypeinterventionalSponsorNational Taiwan University HospitalRan2023 to 2028Enrolled160ConditionsRehabilitation, Pain, Shoulder, Pain, Chronic, Idiopathic ScoliosisArmsLASER, Ultrasound, Prolotherapy
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Novel metabolic and lipidomic biomarkers of sarcopenia.Journal of cachexia, sarcopenia and muscle · 2024
    Article
  2. Review
  3. Lysophosphatidylcholine: Potential Target for the Treatment of Chronic Pain.International journal of molecular sciences · 2022
    Review
  4. Article
  5. Effect ofBiomolecules · 2021
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Wei-Hsiang HsuDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, 40402, Taiwan.
Cheng-Han LeeInstitute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.ORCID http://orcid.org/0000-0003-3642-4115
Yen-Ming ChaoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, 40402, Taiwan.
Ching-Hua KuoDepartment of Pharmacy, National Taiwan University, Taipei, 100, Taiwan.
Wei-Chi KuSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, 24205, Taiwan.
Chih-Cheng ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan. chih@ibms.sinica.edu.tw.ORCID http://orcid.org/0000-0003-4768-5660
Yun-Lian LinDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, 40402, Taiwan. yllin5212@gmail.com.
China Medical University · TWInstitute of Biomedical Sciences, Academia Sinica · TWFu Jen Catholic University · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibromyalgia (FM) is characterized by chronic widespread pain. The pathogenesis of FM remains unclear. No specific biomarkers are available. Animal models of FM may provide an opportunity to explore potential biomarkers in a relative homogenous disease condition. Here, we probed the metabolomics profiles of serum and urine in a mouse model of FM induced by intermittent cold stress (ICS). We focused on the role of acid-sensing ion channel 3 (ASIC3) in the metabolomics profiling because ICS treatment induced chronic widespread muscle pain lasting for 1 month in wild-type (Asic3

Indexed as

Acid Sensing Ion ChannelsAlgorithmsAnimalsBiomarkersChronic PainCold TemperatureDisease Models, AnimalDisease ProgressionFemaleFibromyalgiaMetabolomicsMice, Inbred C57BLMice, KnockoutMyalgiaStress, PhysiologicalAcid Sensing Ion ChannelsASIC3 protein, mouseBiomarkers

Identifiers

PMID31431652
PMCPMC6702159
OpenAlexW2969772886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.