ArticleScientific reports2019
The cortico-rubral and cerebello-rubral pathways are topographically organized within the human red nucleus.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Deep Brain Stimulation for Cerebellar Ataxia: A Systematic Review on Indications, Targets and Outcomes.Cerebellum (London, England) · 2026Pooled it
- Anatomy of Cerebro-cerebellar Circuits in Motor Control.Cerebellum (London, England) · 2026Review
- High-Resolution Diffusion Tensor Imaging of the Cerebellum and Brainstem in Chiari Malformation Type I: Association with Function and Pain.Cerebellum (London, England) · 2026Article
- Stitching brain and spinal cord DTI using cross-correlation registration: toward an atlas of spinal tracts.European radiology experimental · 2025Article
- Atlas-guided brain projection tracts: From regions of interest to tractography 3D rendering.Journal of anatomy · 2025Article
- The human brainstem's red nucleus was upgraded to support goal-directed action.Nature communications · 2025Article
- Track-Weighted Dynamic Functional Connectivity Profiles and Topographic Organization of the Human Pulvinar.Human brain mapping · 2024Article
- Neuropathological findings and in vivo imaging correlates of the red nucleus compared to those of the substantia nigra pars compacta in parkinsonisms.Parkinsonism & related disorders · 2024Article
- Phylogenetic reduction of the magnocellular red nucleus in primates and inter-subject variability in humans.Frontiers in neuroanatomy · 2024Article
- Higher hippocampal diffusivity values in welders are associated with greater R2* in the red nucleus and lower psychomotor performance.Neurotoxicology · 2023Article
- In vivo structural connectome of arousal and motor brainstem nuclei by 7 Tesla and 3 Tesla MRI.Human brain mapping · 2022Article
- Functional connectome of arousal and motor brainstem nuclei in living humans by 7 Tesla resting-state fMRI.NeuroImage · 2022Article
- Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Involvement of the intrinsic functional network of the red nucleus in complex behavioral processing.Cerebral cortex communications · 2022Article
- Qualitative and quantitative detectability of hypertrophic olivary degeneration in T2, FLAIR, PD, and DTI: A prospective MRI study.Frontiers in neurology · 2022Article
- How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?Frontiers in systems neuroscience · 2022Review
- The corticotegmental connectivity as an integral component of the descending extrapyramidal pathway: novel and direct structural evidence stemming from focused fiber dissections.Neurosurgical review · 2021Article
- Striatal topographical organization: Bridging the gap between molecules, connectivity and behavior.European journal of histochemistry : EJH · 2021Review
- Cannabinoid CBNeuropharmacology · 2021Article
- Red nucleus structure and function: from anatomy to clinical neurosciences.Brain structure & function · 2021Review
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Authors and funding
12 authors at 2 institutions in 1 country.
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Abstract
The Red Nucleus (RN) is a large nucleus located in the ventral midbrain: it is subdivided into a small caudal magnocellular part (mRN) and a large rostral parvocellular part (pRN). These distinct structural regions are part of functionally different networks and show distinctive connectivity features: the mRN is connected to the interposed nucleus, whilst the pRN is mainly connected to dentate nucleus, cortex and inferior olivary complex. Despite functional neuroimaging studies suggest RN involvement in complex motor and higher order functions, the pRN and mRN cannot be distinguished using conventional MRI. Herein, we employ high-quality structural and diffusion MRI data of 100 individuals from the Human Connectome Project repository and constrained spherical deconvolution tractography to perform connectivity-based segmentation of the human RN. In particular, we tracked connections of RN with the inferior olivary complex, the interposed nucleus, the dentate nucleus and the cerebral cortex. We found that the RN can be subdivided according to its connectivity into two clusters: a large ventrolateral one, mainly connected with the cerebral cortex and the inferior olivary complex, and a smaller dorsomedial one, mainly connected with the interposed nucleus. This structural topography strongly reflects the connectivity patterns of pRN and mRN respectively. Structural connectivity-based segmentation could represent a useful tool for the identification of distinct subregions of the human red nucleus on 3T MRI thus allowing a better evaluation of this subcortical structure in healthy and pathological conditions.
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