ArticleTranslational psychiatry2019
Hippocampal volume change following ECT is mediated by rs699947 in the promotor region of VEGF.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Antipsychotic selection in combination with electroconvulsive therapy for acute schizophrenia: differential efficacy and safety profiles from a real world study.BMC psychiatry · 2026Article
- A clinical control study of modified electroconvulsive therapy and sodium valproate as enhancement strategies for ultra-treatment-resistant schizophrenia.Schizophrenia research. Cognition · 2026Article
- Transcranial Stimulation Methods in the Treatment of MDD Patients-The Role of the Neurotrophin System.International journal of molecular sciences · 2025Review
- Neurobiological Mechanisms of Electroconvulsive Therapy: Molecular Perspectives of Brain Stimulation.International journal of molecular sciences · 2025Review
- Vascular endothelial growth factor: a key factor in the onset and treatment of depression.Frontiers in cellular neuroscience · 2025Review
- Molecular mechanisms underlying structural plasticity of electroconvulsive therapy in major depressive disorder.Brain imaging and behavior · 2024Article
- How electroconvulsive therapy works in the treatment of depression: is it the seizure, the electricity, or both?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Clinical Improvement in Depression and Cognitive Deficit Following Electroconvulsive Therapy.Diagnostics (Basel, Switzerland) · 2023Review
- Cerebro-cerebellar functional neuroplasticity mediates the effect of electric field on electroconvulsive therapy outcomes.Translational psychiatry · 2023Article
- The Association of Biochemical and Genetic Biomarkers in VEGF Pathway with Depression.Pharmaceutics · 2022Article
- Parsing the Network Mechanisms of Electroconvulsive Therapy.Biological psychiatry · 2022Review
- The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go?Biological psychiatry · 2022Review
- Biomolecular Research on Electroconvulsive Therapy for Mental Disorders: State of the Art and Future Directions.Alpha psychiatry · 2022Article
- SIRT1/FOXO1 Axis-Mediated Hippocampal Angiogenesis is Involved in the Antidepressant Effect of Chaihu Shugan San.Drug design, development and therapy · 2022Article
- Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives.Neuroscience bulletin · 2021Review
- Novel candidate genes for ECT response prediction-a pilot study analyzing the DNA methylome of depressed patients receiving electroconvulsive therapy.Clinical epigenetics · 2020Article
- Electroconvulsive Therapy: Mechanisms of Action, Clinical Considerations, and Future Directions.Harvard review of psychiatryReview
- Melatonin as a Neuroprotective Adjunct in Bipolar Patients Undergoing Electroconvulsive Therapy: A Double-blind Randomized Controlled Trial.Basic and clinical neuroscienceArticle
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have shown that electroconvulsive therapy (ECT) results in increased hippocampal volume. It is likely that a multitude of mechanisms including neurogenesis, gliogenesis, synaptogenesis, angiogenesis, and vasculogenesis contribute to this volume increase. Neurotrophins, like vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) seem to play a crucial mediating role in several of these mechanisms. We hypothesized that two regulatory SNPs in the VEGF and BDNF gene influence the changes in hippocampal volume following ECT. We combined genotyping and brain MRI assessment in a sample of older adults suffering from major depressive disorder to test this hypothesis. Our results show an effect of rs699947 (in the promotor region of VEGF) on hippocampal volume changes following ECT. However, we did not find a clear effect of rs6265 (in BDNF). To the best of our knowledge, this is the first study investigating possible genetic mechanisms involved in hippocampal volume change during ECT treatment.
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