Evidence map›Paper›PMID 31431603›Full record

ArticleClinical and experimental pediatrics2020

Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum.

Joo Hee Seo, Yun-Jin Lee, Ki Hyeong Lee, Elakkat Gireesh, Holly Skinner, Michael Westerveld

Open access · diamondAbstract read
In one paragraph

Article in Clinical and experimental pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Joo Hee SeoComprehensive Epilepsy Center, AdventHealth for Children, Orlando, FL, USA.
Yun-Jin LeeComprehensive Epilepsy Center, AdventHealth for Children, Orlando, FL, USA.
Ki Hyeong LeeComprehensive Epilepsy Center, AdventHealth for Children, Orlando, FL, USA.
Elakkat GireeshComprehensive Epilepsy Center, AdventHealth for Children, Orlando, FL, USA.
Holly SkinnerComprehensive Epilepsy Center, AdventHealth for Children, Orlando, FL, USA.
Michael WesterveldComprehensive Epilepsy Center, AdventHealth for Children, Orlando, FL, USA.
AdventHealth for Children · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in autoimmune encephalitis studies in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder. The disorder or syndrome has been linked to a wide variety of pathologic processes associated with the neuron-specific autoantibodies targeting intracellular and plasma membrane antigens. However, current criteria for autoimmune encephalitis are quite dependent on antibody testing and responses to immunotherapy, which might delay the diagnosis. This form of encephalitis can involve the multifaceted presentation of seizures and unexpected behavioral changes. The spectrum of neuropsychiatric symptoms in children is less definitive than that in adults, and the incorporation of clinical, immunological, electrophysiological, and neuroradiological results is critical to the diagnostic approach. In this review, we document the clinical and immunologic characteristics of autoimmune encephalitis known to date, with the goal of helping clinicians in differential diagnosis and to provide prompt and effective treatment.

Indexed as

Antineuronal antibodiesAutoimmune encephalitisAutoimmune epilepsyEpilepsy in childrenImmunosuppression therapy

Identifiers

PMID31431603
PMCPMC7402981
OpenAlexW2967489252

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.