Evidence map›Paper›PMID 31431557›Full record

ArticlemBio2019

Microsporidia Interact with Host Cell Mitochondria via Voltage-Dependent Anion Channels Using Sporoplasm Surface Protein 1.

Bing Han, Yanfen Ma, Vincent Tu, Tadakimi Tomita, Joshua Mayoral, Tere Williams, Aline Horta, Huan Huang, Louis M Weiss

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. ThebioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Microsporidian EnP1 alters host cell H2B monoubiquitination and prevents ferroptosis facilitating microsporidia survival.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Engineered gut symbiont inhibits microsporidian parasite and improves honey bee survival.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Frontiers in microbiology · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bing HanDepartment of Pathology, Albert Einstein College of Medicine, New York, USA.ORCID 0000-0002-7299-2753
Yanfen MaDepartment of Pathology, Albert Einstein College of Medicine, New York, USA.
Vincent TuDepartment of Pathology, Albert Einstein College of Medicine, New York, USA.
Tadakimi TomitaDepartment of Pathology, Albert Einstein College of Medicine, New York, USA.ORCID 0000-0001-8809-3333
Joshua MayoralDepartment of Pathology, Albert Einstein College of Medicine, New York, USA.
Tere WilliamsDepartment of Pathology, Albert Einstein College of Medicine, New York, USA.
Aline HortaDepartment of Pathology, Albert Einstein College of Medicine, New York, USA.
Huan HuangDepartment of Pathology, Albert Einstein College of Medicine, New York, USA.
Louis M WeissDepartment of Pathology, Albert Einstein College of Medicine, New York, USA louis.weiss@einstein.yu.edu.ORCID 0000-0002-0357-7396
Albert Einstein College of Medicine · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
Microsporidia: invasion apparatusR01AI124753 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2016 to 2025
$4.2M
LTQ Orbitrap Velos Mass Spectrometer SystemS10RR029398 · NCRR · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ANGELETTI, RUTH HOGUE · 2010 to 2010
$963k
120kV Transmission Electron Microscope for a Multi-user Microscopy FacilityS10OD016214 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CONDEELIS, JOHN S · 2014 to 2014
$459k
Secreted effectors of Toxoplasma gondii bradyzoitesF31AI136401 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MAYORAL, JOSHUA ALEXANDER · 2018 to 2019
$83k
NCI NIH HHS P30 CA013330NCRR NIH HHS S10 RR029398NIAID NIH HHS F31 AI136401NIAID NIH HHS R01 AI124753NIH HHS S10 OD016214
6 · The paper itself

Abstract

Microsporidia are opportunistic intracellular pathogens that can infect a wide variety of hosts ranging from invertebrates to vertebrates. During invasion, the microsporidian polar tube pushes into the host cell, creating a protective microenvironment, the invasion synapse, into which the sporoplasm extrudes. Within the synapse, the sporoplasm then invades the host cell, forming a parasitophorous vacuole (PV). Using a proteomic approach, we identified

Indexed as

CytoplasmEncephalitozoonFungal ProteinsGene Knockdown TechniquesGene SilencingHost-Pathogen InteractionsHumansMicrosporidiaMitochondriaMitochondrial Membrane Transport ProteinsProteomicsVoltage-Dependent Anion Channel 1Voltage-Dependent Anion Channel 2Voltage-Dependent Anion ChannelsFungal ProteinsMitochondrial Membrane Transport ProteinsVDAC1 protein, humanVDAC2 protein, humanVDAC3 protein, humanVoltage-Dependent Anion Channel 1Voltage-Dependent Anion Channel 2Voltage-Dependent Anion ChannelsEncephalitozoon hellemmicrosporidiamitochondriaparasitophorous vacuolesporoplasm surface proteinVDACvoltage-dependent anion selective channels

Identifiers

PMID31431557
PMCPMC6703431
OpenAlexW2969343929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.