Evidence map›Paper›PMID 31431501›Full record

ArticleThe Journal of biological chemistry2019

MicroRNA-145 promotes the epithelial-mesenchymal transition in peritoneal dialysis-associated fibrosis by suppressing fibroblast growth factor 10.

Jiayu Wu, Qianyin Huang, Peilin Li, Yuxian Wang, Chenghao Zheng, Xianghong Lei, Shuting Li, Wangqiu Gong, Bohui Yin, Congwei Luo and 6 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Jiayu WuDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.ORCID 0000-0002-4901-6359
Qianyin HuangDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Peilin LiDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Yuxian WangDepartment of Gerontology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Chenghao ZhengSecond Clinical Medical School, Southern Medical University, Guangzhou 510280, China.
Xianghong LeiDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Shuting LiDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Wangqiu GongDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Bohui YinDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Congwei LuoDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Jing XiaoDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Weidong ZhouDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Zhaozhong XuDepartment of Emergency, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Yihua ChenDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China 13724005373@163.com.
Fenfen PengDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China doctorpff@163.com.
Haibo LongDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China longhb1966@163.com.ORCID 0000-0001-6891-8916
Zhujiang Hospital · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peritoneal fibrosis is a common complication of long-term peritoneal dialysis (PD) and the principal cause of ultrafiltration failure during PD. The initial and reversible step in PD-associated peritoneal fibrosis is the epithelial-mesenchymal transition (EMT). Although the mechanisms in the EMT have been the focus of many studies, only limited information is currently available concerning microRNA (miRNA) regulation in peritoneal fibrosis. In this study, we aimed to characterize the roles of microRNA-145 (miR-145) and fibroblast growth factor 10 (FGF10) in peritoneal fibrosis. After inducing EMT with transforming growth factor-β1 (TGF-β1)

Indexed as

3' Untranslated RegionsAnimalsBase SequenceCell LineEpithelial-Mesenchymal TransitionFibroblast Growth Factor 10Gene Knockdown TechniquesHumansMaleMiceMice, Inbred C57BLMicroRNAsPeritoneal DialysisPeritoneal Fibrosis3' Untranslated RegionsFibroblast Growth Factor 10MicroRNAsMIRN145a microRNA, mouseMIRN145 microRNA, humanepithelial-mesenchymal transition (EMT)fibroblast growth factor 10 (FGF10)fibrosiskidney diseasemicroRNA (miRNA)mRNAperitoneal dialysis (PD)renal replacement therapytranslation regulation

Identifiers

PMID31431501
PMCPMC6791318
OpenAlexW2969578920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.