ArticleJournal of the Royal Society, Interface2019
Rapid predictive simulations with complex musculoskeletal models suggest that diverse healthy and pathological human gaits can emerge from similar control strategies.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed.
- Subject-specific muscle properties from diffusion tensor imaging significantly improve the accuracy of musculoskeletal models.Journal of anatomy · 2020Trial
- Cross-bridge model for predicting muscle short-range stiffness during movement.PLoS computational biology · 2026Article
- Simulation study of exoskeleton-musculoskeletal coupling for exoskeleton assistance via multi-agent reinforcement learning.Medical & biological engineering & computing · 2026Article
- From Joint Loading to Osteoarthritis: A Multiscale Review of Knee Mechanobiology and Digital Modelling.International journal of molecular sciences · 2026Review
- GaitDynamics: a generative foundation model for analyzing human walking and running.Nature biomedical engineering · 2026Article
- Why inverse simulations overestimate optimal ankle exoskeleton assistance: the role of bi-articular coordination and joint stiffness.Journal of neuroengineering and rehabilitation · 2026Article
- Simulation-guided design of exotendons to reduce the energetic cost of running.bioRxiv : the preprint server for biology · 2026Article
- Early Imaging Biomarkers of Cartilage Strain After ACL Reconstruction Predict Patient Pain and Altered Knee Loading.Annals of biomedical engineering · 2026Article
- How muscle ageing affects rapid goal-directed movement: mechanistic insights from a simple model.PLoS computational biology · 2026Article
- Reproducible Research: Computational Design of Personalized Clinical Treatments for Walking Impairments Using the Neuromusculoskeletal Modeling Pipeline.bioRxiv : the preprint server for biology · 2026Article
- Simulated gait training improves joint loading symmetry in unilateral transfemoral bone-anchored limb users.Journal of biomechanics · 2026Article
- Pareto-Based Diagnostics and Selection for Mechanics-Synergy Trade-Offs in Unmeasured Muscle Activation Reconstruction.Bioengineering (Basel, Switzerland) · 2026Article
- Feasibility of predicting changes in gait biomechanics following muscle strength perturbations using optimal control in patients with transfemoral amputation.Computer methods in biomechanics and biomedical engineering · 2026Article
- Reducing Complexity in Muscle-Tendon Kinematics Parameterization Improves Convergence Speed in Musculoskeletal Simulations.International journal for numerical methods in biomedical engineering · 2026Article
- Investigating the effects of spring-loaded knee brace stiffness on gait biomechanics through predictive simulation.Scientific reports · 2026Article
- From body hulls to musculoskeletal models: Personalized inertial parameter estimation.PloS one · 2026Article
- Simulations Reveal How Touchdown Kinematic Variables Affect Top Sprinting Speed: Implications for Coaching.Medicine and science in sports and exercise · 2025Article
- Benchmarking the predictive capability of human gait simulations.PLoS computational biology · 2025Article
- Overground gait transitions are not sharp but involve gradually changing walk-run mixtures even over long distances.Royal Society open science · 2025Article
- Estimating the contribution of musculoskeletal impairments to altered gait kinematics in children with cerebral palsy using predictive simulations.Journal of neuroengineering and rehabilitation · 2025Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physics-based predictive simulations of human movement have the potential to support personalized medicine, but large computational costs and difficulties to model control strategies have limited their use. We have developed a computationally efficient optimal control framework to predict human gaits based on optimization of a performance criterion without relying on experimental data. The framework generates three-dimensional muscle-driven simulations in 36 min on average-more than 20 times faster than existing simulations-by using direct collocation, implicit differential equations and algorithmic differentiation. Using this framework, we identified a multi-objective performance criterion combining energy and effort considerations that produces physiologically realistic walking gaits. The same criterion also predicted the walk-to-run transition and clinical gait deficiencies caused by muscle weakness and prosthesis use, suggesting that diverse healthy and pathological gaits can emerge from the same control strategy. The ability to predict the mechanics and energetics of a broad range of gaits with complex three-dimensional musculoskeletal models will allow testing novel hypotheses about gait control and hasten the development of optimal treatments for neuro-musculoskeletal disorders.
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