ReviewJournal of the Royal Society, Interface2019
Growth and remodelling of living tissues: perspectives, challenges and opportunities.
Review in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 245 citations in OpenAlex.
- From Joint Loading to Osteoarthritis: A Multiscale Review of Knee Mechanobiology and Digital Modelling.International journal of molecular sciences · 2026Review
- Mechanochemical modeling of exercise-induced skeletal muscle hypertrophy.PLoS computational biology · 2026Article
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- A minimal mechanically consistent model of smoothly dividing disk-shaped cells.NPJ systems biology and applications · 2026Article
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- Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection.Biomechanics and modeling in mechanobiology · 2025Article
- The sobol sensitivity analysis of the pressure, stresses, and displacement arising from poroelastic modelling of hard mechanical systems.Scientific reports · 2025Article
- A comprehensive framework for computational modeling of growth and remodeling in tissue-engineered soft collagenous materials.Biomechanics and modeling in mechanobiology · 2025Article
- Targeting developmental vulnerabilities in childhood sarcomas.Cancer metastasis reviews · 2025Review
- Article
- Multiscale Kinematic Growth Coupled With Mechanosensitive Systems Biology in Open-Source Software.Journal of biomechanical engineering · 2025Article
- Development and calibration of digital twins for human skin growth in tissue expansion.Acta biomaterialia · 2025Article
- Decellularized Extracellular Matrix-Derived Hydrogels: a Powerful Class of Biomaterials for Skeletal Muscle Regenerative Engineering Applications.Regenerative engineering and translational medicine · 2025Article
- Mechanical Cell Interactions on Curved Interfaces.Bulletin of mathematical biology · 2025Article
- Tissue stresses caused by invasive tumour: a biomechanical model.Journal of the Royal Society, Interface · 2025Article
- Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling.Journal of the Royal Society, Interface · 2025Review
- Simulating irregular symmetry breaking in gut cross sections using a novel energy-optimization approach in growth-elasticity.Journal of theoretical biology · 2024Article
- The morphology of internal elastic lamina corrugations in arteries under physiological conditions.Morphologie : bulletin de l'Association des anatomistes · 2024Article
- Modeling Fatigue Failure of Cartilage and Fibrous Biological Tissues Using Constrained Reactive Mixture Theory.Journal of biomechanical engineering · 2024Article
- FSGe: A fast and strongly-coupled 3D fluid-solid-growth interaction method.Computer methods in applied mechanics and engineering · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most remarkable differences between classical engineering materials and living matter is the ability of the latter to grow and remodel in response to diverse stimuli. The mechanical behaviour of living matter is governed not only by an elastic or viscoelastic response to loading on short time scales up to several minutes, but also by often crucial growth and remodelling responses on time scales from hours to months. Phenomena of growth and remodelling play important roles, for example during morphogenesis in early life as well as in homeostasis and pathogenesis in adult tissues, which often adapt to changes in their chemo-mechanical environment as a result of ageing, diseases, injury or surgical intervention. Mechano-regulated growth and remodelling are observed in various soft tissues, ranging from tendons and arteries to the eye and brain, but also in bone, lower organisms and plants. Understanding and predicting growth and remodelling of living systems is one of the most important challenges in biomechanics and mechanobiology. This article reviews the current state of growth and remodelling as it applies primarily to soft tissues, and provides a perspective on critical challenges and future directions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.