ArticleProceedings. Biological sciences2019
Differences in mitochondrial efficiency explain individual variation in growth performance.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Physiology can predict animal activity, exploration, and dispersal.Communications biology · 2022Pooled it
- Cooperative care influences genome-wide levels of DNA methylation in nestling chestnut-crowned babblers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Ventilatory efficiency: Physiological modelling and mechanistic validation.The Journal of physiology · 2026Article
- Blood mitochondrial metabolism predicts flight performance without lasting effects of early-life thyroid hormones.iScience · 2026Article
- Article
- Inter-Caste Comparison Reveals a Unique Bioenergetic Signature in Long-Lived Ant Queens.Molecular ecology · 2025Article
- Admixture Mapping Reveals Evidence for Multiple Mitonuclear Incompatibilities in Swordtail Fish Hybrids.Molecular ecology · 2025Article
- Article
- ATP and appetite: mitochondrial efficiency predicts meal size and the time until next feeding in common minnows.Royal Society open science · 2025Article
- Does colour-morph variation in metabolic physiology and oxidative stress match morph-specific life-history strategies?Oecologia · 2025Article
- Linking warmer nest temperatures to reduced body size in seabird nestlings: possible mitochondrial bioenergetic and proteomic mechanisms.The Journal of experimental biology · 2025Article
- Mitochondrial methylation is linked to sexually dimorphic growth in Nile tilapia (Frontiers in cell and developmental biology · 2025Article
- Response to 'Commentary on Thoral et al. (2024) The relationship between mitochondrial respiration, resting metabolic rate and blood cell count in great tits'.Biology open · 2024Article
- Mitochondrial efficiency impacts nocturnal sheltering in juvenile salmon (Proceedings. Biological sciences · 2024Article
- Non-lethal sampling for assessment of mitochondrial function does not affect metabolic rate and swimming performance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Tissue-specific metabolic enzyme levels covary with whole-animal metabolic rates and life-history loci via epistatic effects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- An evolving roadmap: using mitochondrial physiology to help guide conservation efforts.Conservation physiology · 2024Article
- The relationships between growth rate and mitochondrial metabolism varies over time.Scientific reports · 2022Article
- Links between host genetics, metabolism, gut microbiome and amoebic gill disease (AGD) in Atlantic salmon.Animal microbiome · 2022Article
- Mice selected for a high basal metabolic rate evolved larger guts but not more efficient mitochondria.Proceedings. Biological sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physiological causes of intraspecific differences in fitness components such as growth rate are currently a source of debate. It has been suggested that differences in energy metabolism may drive variation in growth, but it remains unclear whether covariation between growth rates and energy metabolism is: (i) a result of certain individuals acquiring and consequently allocating more resources to growth, and/or is (ii) determined by variation in the efficiency with which those resources are transformed into growth. Studies of individually housed animals under standardized nutritional conditions can help shed light on this debate. Here we quantify individual variation in metabolic efficiency in terms of the amount of adenosine triphosphate (ATP) generated per molecule of oxygen consumed by liver and muscle mitochondria and examine its effects, both on the rate of protein synthesis within these tissues and on the rate of whole-body growth of individually fed juvenile brown trout (Salmo trutta) receiving either a high or low food ration. As expected, fish on the high ration on average gained more in body mass and protein content than those maintained on the low ration. Yet, growth performance varied more than 10-fold among individuals on the same ration, resulting in some fish on low rations growing faster than others on the high ration. This variation in growth for a given ration was related to individual differences in mitochondrial properties: a high whole-body growth performance was associated with high mitochondrial efficiency of ATP production in the liver. Our results show for the first time, to our knowledge, that among-individual variation in the efficiency with which substrates are converted into ATP can help explain marked variation in growth performance, independent of food intake. This study highlights the existence of inter-individual differences in mitochondrial efficiency and its potential importance in explaining intraspecific variation in whole-animal performance.
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