Evidence map›Paper›PMID 31431085›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Attenuated fibrosis in specific pathogen-free microbiota in experimental cholestasis- and toxin-induced liver injury.

Sheida Moghadamrad, Mohsin Hassan, Kathy D McCoy, Jorum Kirundi, Philipp Kellmann, Andrea De Gottardi

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sheida MoghadamradDepartment of Biomedical Research, Hepatology, University of Berne, Berne, Switzerland.
Mohsin HassanDepartment of Biomedical Research, Hepatology, University of Berne, Berne, Switzerland.
Kathy D McCoyDepartment of Biomedical Research, Gastroenterology, University of Berne, Berne, Switzerland.
Jorum KirundiDepartment of Biomedical Research, Gastroenterology, University of Berne, Berne, Switzerland.
Philipp KellmannDepartment of Biomedical Research, Hepatology, University of Berne, Berne, Switzerland.
Andrea De GottardiDepartment of Biomedical Research, Hepatology, University of Berne, Berne, Switzerland.
University Hospital of Bern · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In advanced chronic liver disease (CLD), the translocation of intestinal bacteria and the resultant increase of proinflammatory cytokines in the splanchnic and systemic circulation may contribute to the progression of fibrosis. We therefore speculated that fibrosis and portal hypertension (PHT) would be attenuated in a mouse model of limited intestinal colonization with altered Schaedler flora (ASF) compared to a more complex colonization with specific pathogen-free (SPF) flora. We induced liver fibrosis in ASF and SPF mice by common bile duct ligation (BDL) or by carbon tetrachloride (CCl

Indexed as

MicrobiotaAnimalsCarbon Tetrachloride PoisoningChemical and Drug Induced Liver InjuryCholestasisHypertension, PortalLiver CirrhosisMaleMicealtered Schaedler florabile duct ligationcarbon tetrachlorideportal hypertensionα-SMA

Identifiers

PMID31431085
PMCPMC6902738
OpenAlexW2969405704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.