Evidence map›Paper›PMID 31431000›Full record

ArticleBiomolecules2019

Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization.

Nilton B Dos Santos, Roseane D Franco, Rosana Camarini, Carolina D Munhoz, Rosangela A S Eichler, Mayara C F Gewehr, Patricia Reckziegel, Ricardo P Llanos, Camila S Dale, Victoria R O da Silva and 17 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

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  3. Neurolysin Knockout Mice in a Diet-Induced Obesity Model.International journal of molecular sciences · 2023
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  11. Peptidome: Chaos or Inevitability.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 5 institutions in 2 countries.

Nilton B Dos SantosDepartment of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Roseane D FrancoDepartment of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Rosana CamariniDepartment of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Carolina D MunhozDepartment of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Rosangela A S EichlerDepartment of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Mayara C F GewehrDepartment of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Patricia ReckziegelDepartment of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Ricardo P LlanosDepartment of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Camila S DaleDepartment of Anatomy, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Victoria R O da SilvaDepartment of Anatomy, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Vanessa F BorgesDepartment of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
Braulio H F LimaDepartment of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
Fernando Q CunhaDepartment of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
Bruna VisniauskasDepartment of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, SP, Brazil.
Jair R ChagasDepartment of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, SP, Brazil.
Sergio TufikDepartment of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, SP, Brazil.
Fernanda F PeresDepartment of Pharmacology, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, SP, Brazil.
Vanessa C AbilioDepartment of Pharmacology, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, SP, Brazil.
Jorge C FlorioDepartment of Pathology, Veterinarian Medical School, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.
Leo K IwaiSpecial Laboratory of Applied Toxinology (LETA), Center of Toxins, Immune Response and Cell Signaling (CETICS), Butantan Institute, São Paulo 05503-900, Brazil.
Vanessa RioliSpecial Laboratory of Applied Toxinology (LETA), Center of Toxins, Immune Response and Cell Signaling (CETICS), Butantan Institute, São Paulo 05503-900, Brazil.
Benedito C PresotoPharmacology Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.
Alessander O GuimaraesDepartment of Biophysics, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, SP, Brazil.
Joao B PesqueroDepartment of Biophysics, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, SP, Brazil.
Michael BaderMax-Delbrück-Center for Molecular Medicine, D-13125 Berlin, Germany.
Leandro M CastroBiosciences Institute, São Paulo State University (UNESP), 11330-900 São Vicente, SP, Brazil.
Emer S FerroDepartment of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil. eferro@usp.br.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRInstituto Butantan · BRMax Delbrück Center · DEUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1

Indexed as

AnimalsBehavior, AnimalFemaleMaleMetalloendopeptidasesMiceMice, Inbred C57BLMice, KnockoutPhenotypeMetalloendopeptidasesthimet oligopeptidaseinflammationMHC-IneurodegenerationpeptidomesepsisTHOP1

Identifiers

PMID31431000
PMCPMC6722639
OpenAlexW2967505236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.