Evidence map›Paper›PMID 31430749›Full record

ArticleNeuroepidemiology2019

High Prevalence of Dystonia in the Faroe Islands: A Population-Based Study.

Elan D Louis, Eina H Eliasen, Christine Y Kim, Monica Ferrer, Shahin Gaini, Maria Skaalum Petersen

Open access · bronzeAbstract read
In one paragraph

Article in Neuroepidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Elan D LouisDepartment of Neurology, Yale School of Medicine, Yale University, New Haven, Connecticut, USA, elan.louis@yale.edu.
Eina H EliasenDepartment of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faeroe Islands.
Christine Y KimDepartment of Neurology, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Monica FerrerDepartment of Neurology, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Shahin GainiCentre for Health Science, Faculty of Health Sciences, University of the Faroe Islands, Tórshavn, Faeroe Islands.
Maria Skaalum PetersenDepartment of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faeroe Islands.
University of the Faroe Islands · FOYale University · US

Funding

ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORR01NS039422 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2000 to 2013
$7.7M
Environmental Epidemiology of Essential TremorR01NS094607 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2016 to 2020
$3.9M
NINDS NIH HHS R01 NS039422NINDS NIH HHS R01 NS094607
6 · The paper itself

Abstract

backgroundThere are fewer than 5 population-based studies of dystonia worldwide. Only one utilized a movement disorders neurologist. Given the potential for founder effects, and the highly genetic nature of dystonia, the Faroe Islands provide a particularly interesting setting to study the prevalence of dystonia.

objectiveTo estimate the prevalence of dystonia.

methodsWe used a 2-phase, population-based design, screening 1,334 randomly selected Faroese individuals aged ≥40 years from which a subsample of 227 participated in an in-person clinical evaluation. Dystonia was assessed by 2 movement disorder neurologists using videotaped examinations.

resultsTwo of 227 (0.88%, 95% CI -0.33 to 2.09%) were diagnosed with cervical or segmental dystonia. An unusual form of thumb flexion dystonia was noted in 75 more, yielding a combined prevalence of 33.92% (95% CI 27.73-40.11%).

conclusionsThe prevalence of cervical or segmental dystonia was as high as in one prior population-based study using similar methods. Furthermore, an unusual form of thumb flexion dystonia was uncovered, which yielded an extraordinarily high prevalence of dystonia in this population. Although our methods likely contributed to more complete capture of subtle dystonia, founder effects are highly likely to have been an additional major contributor to these findings.

Indexed as

AgedDenmarkDystoniaFemaleFounder EffectGenetic Predisposition to DiseaseHumansMalePrevalenceDystoniaFaroe IslandsPrevalenceTwo-phase population-based design

Identifiers

PMID31430749
PMCPMC6881520
OpenAlexW2976127793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.