Evidence map›Paper›PMID 31430449›Full record

ArticleDevelopmental cell2019

Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics.

Caroline Vissers, Ryoichiro Kageyama

Abstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Caroline VissersThe Graduate Program of Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Ryoichiro KageyamaInstitute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto 606-8501, Japan. Electronic address: kageyama.ryoichiro.8r@kyoto-u.ac.jp.

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

In this issue of Developmental Cell,Lee et al. (2019) and Falo-Sanjuan et al. (2019) examine the transcriptional dynamics of Notch signaling in vivo. Both groups show that Notch signaling produces "bursty" transcriptional responses and that variance in these responses stems from changes in duration, not frequency, of transcriptional bursts.

Indexed as

Signal Transduction

Identifiers

PMID31430449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.