ArticlePLoS biology2019
Identification of traits and functional connectivity-based neurotraits of chronic pain.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Development and Initial Validation of Mindfulness-Based Pain Reduction (MBPR) in Patients With Chronic Low Back Pain.Journal of pain research · 2025Trial
- Visualizing pain-processing networks with 7T resting-state functional MRI using pseudo-continuous arterial spin labeling.Scientific reports · 2026Article
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- Decoding pain: uncovering the factors that affect the performance of neuroimaging-based pain models.Pain · 2025Article
- Interindividual differences in pain can be explained by fMRI, sociodemographic, and psychological factors.Nature communications · 2024Article
- An externally validated resting-state brain connectivity signature of pain-related learning.Communications biology · 2024Article
- Article
- Research on the multidimensional brain remodeling mechanisms at the level of brain regions, circuits, and networks in patients with chronic lower back pain caused by lumbar disk herniation.Frontiers in neuroscience · 2024Article
- Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain.Neuron · 2023Article
- Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia.Nature reviews. Rheumatology · 2023Review
- Chronic pain domains and their relationship to personality, abilities, and brain networks.Pain · 2023Article
- The Impact of Quarantine on Pain Sensation among the General Population in China during the COVID-19 Pandemic.Brain sciences · 2022Article
- Article
- Brain markers predicting response to cognitive-behavioral therapy for social anxiety disorder: an independent replication of Whitfield-Gabrieli et al. 2015.Translational psychiatry · 2021Article
- The Necessity of Methodological Advances in Pain Research: Challenges and Opportunities.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- PRG-1 relieves pain and depressive-like behaviors in rats of bone cancer pain by regulation of dendritic spine in hippocampus.International journal of biological sciences · 2021Article
- Recommendations for the Development of Socioeconomically-Situated and Clinically-Relevant Neuroimaging Models of Pain.Frontiers in neurology · 2021Article
- Article
- Evaluating Cortical Alterations in Patients With Chronic Back Pain Using Neuroimaging Techniques: Recent Advances and Perspectives.Frontiers in psychology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Psychological and personality factors, socioeconomic status, and brain properties all contribute to chronic pain but have essentially been studied independently. Here, we administered a broad battery of questionnaires to patients with chronic back pain (CBP) and collected repeated sessions of resting-state functional magnetic resonance imaging (fMRI) brain scans. Clustering and network analyses applied on the questionnaire data revealed four orthogonal dimensions accounting for 56% of the variance and defining chronic pain traits. Two of these traits-Pain-trait and Emote-trait-were associated with back pain characteristics and could be related to distinct distributed functional networks in a cross-validation procedure, identifying neurotraits. These neurotraits showed good reliability across four fMRI sessions acquired over five weeks. Further, traits and neurotraits all related to the income, emphasizing the importance of socioeconomic status within the personality space of chronic pain. Our approach is a first step in providing metrics aimed at unifying the psychology and the neurophysiology of chronic pain applicable across diverse clinical conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.