Evidence map›Paper›PMID 31430178›Full record

ReviewAnnual review of genetics2019

Crossover Interference: Shedding Light on the Evolution of Recombination.

Sarah P Otto, Bret A Payseur

Abstract readReview
In one paragraph

Review in Annual review of genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. High-resolution global recombination mapping inbioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Sex differences in crossover interference in house mice.bioRxiv : the preprint server for biology · 2025
    Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sarah P OttoDepartment of Zoology & Biodiversity Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada; email: otto@zoology.ubc.ca.
Bret A PayseurLaboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Funding

The Genetics and Evolution of Extreme Body Size in Mice from Gough IslandR01GM100426 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PAYSEUR, BRET A · 2012 to 2020
$3.6M
Evolution of the Genome-wide Recombination Rate in MiceR01GM120051 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PAYSEUR, BRET A · 2017 to 2020
$2.4M
NIGMS NIH HHS R01 GM100426NIGMS NIH HHS R01 GM120051
6 · The paper itself

Abstract

Through recombination, genes are freed to evolve more independently of one another, unleashing genetic variance hidden in the linkage disequilibrium that accumulates through selection combined with drift. Yet crossover numbers are evolutionarily constrained, with at least one and not many more than one crossover per bivalent in most taxa. Crossover interference, whereby a crossover reduces the probability of a neighboring crossover, contributes to this homogeneity. The mechanisms by which interference is achieved and crossovers are regulated are a major current subject of inquiry, facilitated by novel methods to visualize crossovers and to pinpoint recombination events. Here, we review patterns of crossover interference and the models built to describe this process. We then discuss the selective forces that have likely shaped interference and the regulation of crossover numbers.

Indexed as

Crossing Over, GeneticDNA Breaks, Double-StrandedModels, GeneticRecombination, GeneticAnimalsDrosophilaFemaleHumansMaleMiceModels, StatisticalSelection, GeneticSpecies SpecificityTelomerecrossoversevolutioninterferencerecombination

Identifiers

PMID31430178
PMCPMC8715713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.