ArticleGenome biology2019
Diurnal regulation of SDG2 and JMJ14 by circadian clock oscillators orchestrates histone modification rhythms in Arabidopsis.
Article in Genome biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 42 citations in OpenAlex.
- Decoding chromatin-associated RNA (caRNA) interaction networks: from genome-wide dynamic capture to epigenetic mechanisms in plants and animals.Epigenetics · 2026Review
- TIME FOR COFFEE coordinates phase separation and chromatin regulation for salt tolerance.Science advances · 2026Article
- Circadian oscillations in chromatin accessibility systematically orchestrate rhythmic gene transcription in soybean.The Plant cell · 2026Article
- H3K4me2 orchestrates H2A.Z and Polycomb repressive marks in Arabidopsis.Nature communications · 2025Article
- Transcriptional activation and repression in the plant circadian clock: Revisiting core oscillator feedback loops and output pathways.Plant communications · 2025Review
- Linker histones enhance robustness in diurnal transcription dynamics.Quantitative plant biology · 2025Article
- The GTE4-EML chromatin reader complex concurrently recognizes histone acetylation and H3K4 trimethylation in Arabidopsis.The Plant cell · 2024Article
- Circadian and photoperiodic regulation of the vegetative to reproductive transition in plants.Communications biology · 2024Review
- BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis.Molecular therapy. Nucleic acids · 2023Article
- Spatially specific mechanisms and functions of the plant circadian clock.Plant physiology · 2022Review
- Integration of rhythmic metabolome and transcriptome provides insights into the transmission of rhythmic fluctuations and temporal diversity of metabolism in rice.Science China. Life sciences · 2022Article
- Open chromatin interaction maps reveal functional regulatory elements and chromatin architecture variations during wheat evolution.Genome biology · 2022Article
- Diurnal RNAPII-tethered chromatin interactions are associated with rhythmic gene expression in rice.Genome biology · 2022Article
- Involvement of JMJ15 in the dynamic change of genome-wide H3K4me3 in response to salt stress.Frontiers in plant science · 2022Article
- Article
- An epigenetic basis of inbreeding depression in maize.Science advances · 2021Article
- TheGenes · 2021Article
- Recognition of CCA1 alternative protein isoforms during temperature acclimation.Plant cell reports · 2021Article
- Histone posttranslational modifications rather than DNA methylation underlie gene reprogramming in pollination-dependent and pollination-independent fruit set in tomato.The New phytologist · 2021Article
- Dietary Conjugated Linoleic Acid Modulates the Hepatic Circadian Clock ProgramFrontiers in nutrition · 2021Article
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundCircadian rhythms modulate growth and development in all organisms through interlocking transcriptional-translational feedback loops. The transcriptional loop involves chromatin modifications of central circadian oscillators in mammals and plants. However, the molecular basis for rhythmic epigenetic modifications and circadian regulation is poorly understood.
resultsHere we report a feedback relationship between diurnal regulation of circadian clock genes and histone modifications in Arabidopsis. On one hand, the circadian oscillators CCA1 and LHY regulate diurnal expression of genes coding for the eraser (JMJ14) directly and writer (SDG2) indirectly for H3K4me3 modification, leading to rhythmic H3K4me3 changes in target genes. On the other hand, expression of circadian oscillator genes including CCA1 and LHY is associated with H3K4me3 levels and decreased in the sdg2 mutant but increased in the jmj14 mutant. At the genome-wide level, diurnal rhythms of H3K4me3 and another histone mark H3K9ac are associated with diurnal regulation of 20-30% of the expressed genes. While the majority (86%) of H3K4me3 and H3K9ac target genes overlap, only 13% of morning-phased and 22% of evening-phased genes had both H3K4me3 and H3K9ac peaks, suggesting specific roles of different histone modifications in diurnal gene expression.
conclusionsCircadian clock genes promote diurnal regulation of SDG2 and JMJ14 expression, which in turn regulate rhythmic histone modification dynamics for the clock and its output genes. This reciprocal regulatory module between chromatin modifiers and circadian clock oscillators orchestrates diurnal gene expression that governs plant growth and development.
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