Evidence map›Paper›PMID 31429784›Full record

ArticleArthritis research & therapy2019

Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis.

Chie Miyabe, Yoshishige Miyabe, Jun Nagai, Noriko N Miura, Naohito Ohno, Jerold Chun, Ryoji Tsuboi, Hiroshi Ueda, Masayuki Miyasaka, Nobuyuki Miyasaka and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Generation of New Knock-Out Mouse Strains ofInternational journal of molecular sciences · 2025
    Article
  3. Review
  4. Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. The roles of autotaxin/lysophosphatidic acid in immune regulation and asthma.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chie MiyabeDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Yoshishige MiyabeDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Jun NagaiDivision of Molecular and Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Noriko N MiuraLaboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Naohito OhnoLaboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Jerold ChunDepartment of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA.
Ryoji TsuboiDepartment of Dermatology, Tokyo Medical University, Tokyo, Japan.
Hiroshi UedaDivision of Molecular and Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Masayuki MiyasakaInterdisciplinary Program for Biomedical Sciences, Osaka University, Osaka, Japan.
Nobuyuki MiyasakaDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Toshihiro NankiDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. toshihiro.nanki@med.toho-u.ac.jp.ORCID 0000-0002-3482-074X

Funding

Prenatal blood-borne lipids in post-hemorrhagic hydrocephalusR01NS084398 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI CHUN, JEROLD · 2014 to 2017
$2.6M
NINDS NIH HHS R01 NS084398
6 · The paper itself

Abstract

backgroundLysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA

methodsATX and LPA receptor expressions were analyzed by immunohistochemistry and quantitative reverse transcription-polymerase chain reaction. Effects of LPA

resultsATX and LPA

conclusionsThese results suggest that LPA-LPA

Indexed as

AnimalsCell MovementCephalosporinsChemokine CXCL1Disease Models, AnimalEnzyme-Linked Immunosorbent AssayHumansImmunohistochemistryInterleukin-8MaleMiceMice, Inbred C57BLNeutrophilsReceptors, Lysophosphatidic AcidSignal TransductionVasculitiscefditorenCephalosporinsChemokine CXCL1CXCL1 protein, humanInterleukin-8Receptors, Lysophosphatidic AcidChemokineLipid mediatorNeutrophilVasculitis

Identifiers

PMID31429784
PMCPMC6702724

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.