ArticleBMC veterinary research2019
Natural chemotherapeutic alternatives for controlling of haemonchosis in sheep.
Article in BMC veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 35 citations in OpenAlex.
- Light-defined cold acclimation reprograms organ-specific metabolic and transcriptional landscapes for salt stress responses in maize.Plant cell reports · 2026Article
- Metabolomic and proteomic differences in susceptible and benzimidazole-resistant adult females and males of Haemonchus contortus.Veterinary research · 2025Article
- Chicory modulates the rumen environment in lambs with endoparasites.Scientific reports · 2025Article
- Insights into the role of bioactive plants for lambs infected withFrontiers in veterinary science · 2025Article
- Effect of zinc oxide nanoparticle supplementation on parasite infection and rumen environment of grazing lambs.Frontiers in veterinary science · 2025Article
- Rumen fermentation and microbiota in Shami goats fed on condensed tannins or herbal mixture.BMC veterinary research · 2024Article
- Antibody response and abomasal histopathology of lambs with haemonchosis during supplementation with medicinal plants and organic selenium.Veterinary and animal science · 2023Article
- DoesHelminthologia · 2022Article
- Impact of Sainfoin (Pathogens (Basel, Switzerland) · 2022Article
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- Effects of Medicinal Plants and Organic Selenium against Ovine Haemonchosis.Animals : an open access journal from MDPI · 2021Article
- Effect ofAnimals : an open access journal from MDPI · 2021Article
- Impact of Zinc and/or Herbal Mixture on Ruminal Fermentation, Microbiota, and Histopathology in Lambs.Frontiers in veterinary science · 2021Article
- Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection?Antioxidants (Basel, Switzerland) · 2020Article
- Small Ruminant Production Based on Rangelands to Optimize Animal Nutrition and Health: Building an Interdisciplinary Approach to Evaluate Nutraceutical Plants.Animals : an open access journal from MDPI · 2020Review
- Natural Compounds from the Marine Brown AlgaPathogens (Basel, Switzerland) · 2020Article
- Anthelmintic Activity of Wormwood (Animals : an open access journal from MDPI · 2020Article
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParallel in vitro and in vivo experiments were designed to evaluate promising chemotherapeutic alternatives for controlling haemonchosis in ruminants. In vitro anthelmintic activities (egg hatch test - EHT; larval development test - LDT) of aqueous and methanolic herbal extracts Mix1 and Mix2 were investigated. The in vivo effects of dietary supplementation with Mix1 and Mix2 on the parasitological status, inflammatory response, antioxidant parameters and microbial community of the lambs infected experimentally with Haemonchus contortus were investigated. Lambs were divided into four groups for the in vivo study: uninfected control lambs (C), infected lambs (I), infected lambs supplemented with Mix1 (I + Mix1) and infected lambs supplemented with Mix2 (I + Mix2). The experimental period was 70 days.
resultsThe number of eggs per gram (EPG) of feces was quantified 22, 30, 37, 44, 51, 58, 65 and 70 days post-infection, and mean abomasal worm counts were assessed 70 days post-infection. Quantitative analyses identified 57.3 and 22.2 mg/g phenolic acids, 41.5 and 29.5 mg/g flavonoids and 1.4 and 1.33 mg/g protoberberine-type alkaloids in Mix1 and Mix2, respectively. The methanolic extracts of the herbal mixtures in both in vitro tests had higher anthelmintic effects (P < 0.01) than the aqueous extracts, but the effects did not differ significantly between Mix1 and Mix2 (P > 0.05). I + Mix1 and I + Mix2 lowered mean EPGs between 44 and 70 d by 58.1 and 51.6%, respectively. The level of IgG antibodies against H. contortus increased significantly after infection in each infected group.
conclusionThese results represent the first monitoring of the in vitro anthelmintic effects of herbal mixtures on H. contortus. The in vivo experiment indicated that the anthelmintic effect was not sufficient for the elimination of parasites, but this herbal treatment may affect the host over a longer term, reducing the parasitic infection in the host.
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