ArticleBMC surgery2019
C-reactive protein elevation ratio as an early predictor of postoperative severe complications after laparoscopic gastrectomy for gastric cancer: a retrospective study.
Article in BMC surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 24 citations in OpenAlex.
- Feasibility and safety of the synchroseal articulating bipolar energy-based device for robotic gastrectomy in patients with gastric cancer: a prospective single-arm clinical trial with historical controls.Updates in surgery · 2025Trial
- Association Between C-Reactive Protein-to-Albumin Ratio and Length of Hospital Stay in Elderly Patients with Acute Appendicitis: A Mediation Analysis of Complicated Appendicitis.Clinical interventions in aging · 2026Article
- Development of a prognostic model for major postoperative complications in gastric cancer patients undergoing laparoscopic gastrectomy.Frontiers in surgery · 2026Article
- Prediction of postoperative infections by strategic data imputation and explainable machine learning.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Time-sequential prediction of postoperative complications after gastric cancer surgery using machine learning: a multicenter cohort study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025Article
- C-reactive protein and digestive pathologies: A narrative review for daily clinical use.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- Optimizing clinical nutrition practices: impact of a formulary prescription-based nutrition therapy protocol in surgical patients.Frontiers in nutrition · 2025Article
- CRP to Albumin Ratio as a Prognostic Nutrition-Based Biomarker for Patients With Gastric Cancer: A Narrative Review.Cureus · 2024Review
- C-reactive protein (CRP) trajectory as a predictor of anastomotic leakage after rectal cancer resection: A multicentre cohort study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Article
- C-reactive protein adjusted for body mass index as a predictor of postoperative complications following laparoscopic gastrectomy for gastric cancer.Langenbeck's archives of surgery · 2021Article
- Clinical significance and prognostic value of C-reactive protein/albumin ratio in gastric cancer.Annals of surgical treatment and research · 2021Article
- Can intraoperative endoscopy prevent esophagojejunal anastomotic leakage after total gastrectomy?HippokratiaArticle
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn gastrectomy, postoperative elevation of C-reactive protein (CRP) is thought to be useful for predicting complications. Laparoscopic gastrectomy (LG) is less invasive than laparotomy and the elevation of CRP is also mild. Postoperative complications such as anastomotic leakage not only increase the severity of the condition, but also carry a poor prognosis when treatment is delayed. Early treatment is therefore necessary.
methodThis retrospective study examined the relationship between occurrence of complications and the ratio of CRP levels on postoperative days 1 and 3 (CRP ratio) for 449 gastric cancer patients who underwent LG in the Department of Gastrointestinal Surgery at Osaka City University Hospital between 2006 and 2016.
resultsWe observed that factors associated with postoperative complications were preoperative renal failure and CRP ratio. No significant associations with surgical procedure, operation time, bleeding volume, age, obesity, measured CRP concentration, or white blood cell count were evident. The optimal cut-off for CRP ratio to predict postoperative complications from the receiver operating characteristic curve was 2.13.
conclusionOur results suggested that the risk of severe postoperative complications after LG could be predicted using the CRP ratio.
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